10007812  Monoacylglycerol Lipase (human recombinant)

MAGL; MGL

Click image to enlarge

• See below for pricing and ordering
• See analysis tools
• See more Enzyme Activity; Protein Array; Western Blot; Enzymes; Proteins; Recombinant Proteins; Neuroscience; Obesity

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Source: human recombinant N-terminal hexa-histidine tagged protein expressed in E. coli · Mr: 34 kDa · Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonyl ethanolamide (AEA) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function.1,2 MGL is the principal 2-AG hydrolase in the mammalian brain accounting for greater than 80% of the total 2-AG hydrolase activity.3 Human recombinant MGL was characterized using 4-nitrophenylacetate as a substrate, which upon hydrolysis by MGL, froms 4-nitrophenol with an absorbance maximum at 412 nm.
1  Dinh, T.P., Freund, T.F., Piomelli, D. A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation. Chem Phys Lipids 121 149-158 (2002).
2  Vila, A., Rosengarth, A., Piomelli, D., et al. Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase. Biochemistry 46 9578-9585 (2007).
3  Blankman, J.L., Simon, G.M., Cravatt, B.F. A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chemistry & Biology 14 1347-1356 (2007).


Purchase 10007812 Monoacylglycerol Lipase (human recombinant)

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-19.
Prices are subject to change without notice.

  email: password: hide x LOGIN | REGISTER
Cayman Chemical
Topical Catalogs
Packed with articles, the latest products, and much more.

New
Eicosanoid

Allergy, Asthma, & Inflammation

Cancer

More...
Helping to make your research possible by providing quality biochemicals and assays for research in and much more.
toll free 800.364.9897
direct dial 734.971.3335
1180 East Ellsworth Road
Ann Arbor, Michigan 48108
USA
All contact info
© 2002-2010
Cayman Chemical