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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Monoacylglycerol Lipase (human recombinant)

Cayman Chemical Item Number 10007812

MAGL; MGL

Monoacylglycerol Lipase (human recombinant)

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Description

Source: human recombinant N-terminal hexa-histidine tagged protein expressed in E. coli · Mr: 34 kDa · Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonyl ethanolamide (AEA) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function.1,2 MGL is the principal 2-AG hydrolase in the mammalian brain accounting for greater than 80% of the total 2-AG hydrolase activity.3 Human recombinant MGL was characterized using 4-nitrophenylacetate as a substrate, which upon hydrolysis by MGL, froms 4-nitrophenol with an absorbance maximum at 412 nm.

1 Dinh, T.P., Freund, T.F., and Piomelli, D. A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation. Chem Phys Lipids 121 149-158 (2002).

2 Vila, A., Rosengarth, A., Piomelli, D., et al. Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase. Biochemistry 46 9578-9585 (2007).

3 Blankman, J.L., Simon, G.M., and Cravatt, B.F. A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem Biol 14 1347-1356 (2007).

Synonyms
  • MAGL
  • MGL
Formulation 50 mM Hepes, pH 7.4, containing 100 mM sodium chloride, 5 mM magnesium chloride, 0.1% Trition, and 25% glycerol
Purity >95%
Stability 6 months
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere

Background Reading

Dinh, T.P., Freund, T.F., and Piomelli, D. A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation. Chem Phys Lipids 121 149-158 (2002).

Vila, A., Rosengarth, A., Piomelli, D., et al. Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase. Biochemistry 46 9578-9585 (2007).

Blankman, J.L., Simon, G.M., and Cravatt, B.F. A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem Biol 14 1347-1356 (2007).
Size Price Quantity Subtotal
10 µg $70.00 $0.00
25 µg $166.00 $0.00
50 µg $315.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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