10007818  Serum Retinol Binding Protein 4 (human recombinant)

RBP4; sRBP4

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• See more Fluorescence; Proteins; Recombinant Proteins; Diabetes; Endocrinology; Metabolic Syndrome; Obesity

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Source: recombinant His-tagged protein purified from E. coli · Mr: ~21 kDa · Human serum retinol binding protein 4 (sRBP4) binds to one equivalent of vitamin A and is one of the major retinol carriers found in the blood of mammals.1,2 Human sRBP4 is a monomeric 21 kDa β-sheet-rich protein that contains three disulfide bonds and belongs to the lipocalin protein family.3 In plasma, sRBP4 typically forms a 1:1 complex with the 55 kDa tetrameric protein transthyretin (TTR) which prevents RBP from being removed from the plasma by glomerular filtration.4 Recent studies have shown that sRBP4 is an adipocyte-derived “signal” that may contribute to the pathogenesis of type 2 diabetes.5,6 Elevation of sRBP4 causes systemic insulin resistance, whereas reduced serum concentrations of sRBP4 improves insulin action.5,7,8 Cayman’s human recombinant sRBP4 contains a C-terminal hexahistidine tag. The purified protein was characterized for its retinol binding activity.
1  Noy, N. Retinoid-binding proteins: Mediators of retinoid action. Biochem J 348 481-495 (2000).
2  Xie, Y., Lashuel, H.A., Miroy, G.J., et al. Recombinant human retinol-binding protein refolding, native disulfide formation, and characterization. Protein Expression and Purification 14 31-37 (1998).
3  Cowan, S.W., Newcomer, M.E., Jones, T.A. Crystallographic refinement of human serum retinol binding protein at 2Å resolution. Proteins: Structure, Function, and Genetics 8, 44-61 (1990).
4  Sivaprasadarao, A., Findlay, J.B.C. Expression of functional human retinol-binding protein in Escherichia coli using a secretion vector. Biochem J 296 209-215 (1993).
5  Yang, Q., Graham, T.E., Mody, N., et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 436 356-362 (2005).
6  Muoio, D.M., Newgard, C.B. A is for adipokine. Nature News and Views 436 337-338 (2005).
7  Graham, T.E., Yang, Q., Blüher, M., et al. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med 354(24) 2552-2563 (2006).
8  Polonsky, K.S. Retinol-binding protein 4, insulin resistance, and type 2 diabetes. N Engl J Med 354(24) 2596-2598 (2006).


Purchase 10007818 Serum Retinol Binding Protein 4 (human recombinant)

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-16.
Prices are subject to change without notice.

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