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10007820 5-Lipoxygenase (Phospho-Ser523) Polyclonal Antibody
5-LO (Phospho-Ser523) Polyclonal Antibody
5-Lipoxygenase (Phospho-Ser523) Polyclonal Antibody Workbook Links
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Antigen:
phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser523 of human 5-lipoxygenase (5-LO)
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Host:
rabbit
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Application(s):
WB
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The enzyme 5-lipoxygenase (5-LO) plays a key role in regulating the production of leukotrienes (LTs).1 Overproduction of LTs contributes to several diseases, most notably chronic inflammatory diseases such as asthma, fibrosis,2 and atherosclerosis. Recent work has demonstrated that the activity of 5-LO is regulated by protein kinase A (PKA) phosphorylation of serine-523 in 5-LO. Under normal conditions, this phosphorylation may be important in limiting inflammation. Abnormal signaling through cAMP and PKA, may therefore contribute to a variety of diseases, including those characterized by chronic inflammation. The phospho-specific antibody to Ser523 on 5-LO provides a valuable tool for studying the role of 5-LO regulation in diseases such as asthma, fibrosis, and atherosclerosis.
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1
Funk, C.D. Prostaglandins and leukotrienes: Advances in eicosanoid biology. Science 294 1871-1875 (2001).
2
Wilborn, J., Bailie, M., Coffey, M., et al. Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis. J Clin Invest 97 1827-1836 (1996).
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Purchase 10007820 5-Lipoxygenase (Phospho-Ser523) Polyclonal Antibody
Pricing is for North America only. Other customers should contact a distributor in their region.
This product is also available to buy in bulk quantities.
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for a quote or to purchase.
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Warning This product is not for human or veterinary use.
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Pricing updated 2010-03-17.
Prices are subject to change without notice.
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