See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

PLC thio-PIP2 (sodium salt)

Cayman Chemical Item Number 10007839

PLC thio-PIP2 (sodium salt)

See more

Description

Phospholipase C (PLC) catalyzes the hydrolysis of phosphatidylinositol (4,5) bisphosphate (PIP2) on the cytoplasmic side of the cell membrane to yield diacylglycerol and inositol-1,4,5-triphosphate (IP3).1,2,3 This reaction initiates a well-known signal transduction pathway common to most cells. PLC thio-PIP2 is an analog of naturally occurring PIP2 that contains sulfur rather than oxygen at the sn-3 position of the glycerol backbone. Hydrolysis by PLC yields a free thiol which reacts with chromogenic reagents such as DTNB (Ellman’s reagent) to allow quantitation of PLC activity.

1 Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36 481-509 (1996).

2 Exton, J.H. Cell signalling through guanine-nucleotide-binding regulatory proteins (G proteins) and phospholipases. Eur J Biochem 243 10-20 (1997).

3 Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

Formal Name 3-​(3-​(1,​2-​dihydroxy-​1,​2-​dihexanoyl)thiopropane)inositol-​4,​5-​diphosphate,​ trisodium salt
Molecular Formula C21H38O18P3S · 3Na
Formula Weight 772.5
Formulation A lyophilized powder
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
CCCCCC(=O)​O[C@H]​(COC(=O)​CCCCC)​CSP(=O)​(O)​O[C@H]​1C(O)​[C@@H]​(C)​C(C)​[C@@H]​(O)​[C@H]​1O

Background Reading

Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36 481-509 (1996).

Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

Exton, J.H. Cell signalling through guanine-nucleotide-binding regulatory proteins (G proteins) and phospholipases. Eur J Biochem 243 10-20 (1997).
Size Price Quantity Subtotal
100 µg $92.00 $0.00
500 µg $414.00 $0.00
1 mg $736.00 $0.00
5 mg $3,220.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

PtdIns-(1,2-dihexanoyl) (sodium salt) Exclusive
PtdIns-(1,2-dioctanoyl) (sodium salt)
PtdIns-(1,2-dipalmitoyl) (ammonium salt)
PtdIns-(3,4,5)-P3 (1,2-dioctanoyl) (sodium salt)
PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)
PtdIns-(3,4,5)-P3 (1-stearoyl, 2-arachidonoyl) (sodium salt)
PtdIns-(3,4)-P2 (1,2-dihexanoyl) (sodium salt)
PtdIns-(3,4)-P2 (1,2-dioctanoyl) (sodium salt)
PtdIns-(3,4)-P2 (1,2-dipalmitoyl) (sodium salt)
PtdIns-(3,5)-P2 (1,2-dihexanoyl) (sodium salt)
PtdIns-(3,5)-P2 (1,2-dioctanoyl) (sodium salt)
PtdIns-(3,5)-P2 (1,2-dipalmitoyl) (sodium salt)
PtdIns-(3)-P1 (1,2-dioctanoyl) (sodium salt)
PtdIns-(3)-P1 (1,2-dipalmitoyl) (ammonium salt)
PtdIns-(3)-P1 (1,2-dipalmitoyl)-d62 (ammonium salt)
PtdIns-(4,5)-P2 (1,2-dihexanoyl) (sodium salt)
PtdIns-(4,5)-P2 (1,2-dioctanoyl) (sodium salt)
PtdIns-(4,5)-P2 (1,2-dipalmitoyl) (ammonium salt)
PtdIns-(4,5)-P2 (1,2-dipalmitoyl) (sodium salt)
PtdIns-(4,5)-P2 Binding Protein
PtdIns-(4)-P1 (1,2-dihexanoyl) (sodium salt)
PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)
PtdIns-(4)-P1 (1,2-dipalmitoyl) (ammonium salt)
PtdIns-(5)-P1 (1,2-dihexanoyl) (sodium salt)
PtdIns-(5)-P1 (1,2-dioctanoyl) (ammonium salt)
PtdIns-(5)-P1 (1,2-dipalmitoyl) (ammonium salt)
Ptd(S)Ins-(3,4)-P2 (1,2-dioctanoyl) (sodium salt)
Ptd(S)Ins-(3,4)-P2 (1,2-dipalmitoyl) (sodium salt) Exclusive
Show all 28 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?