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9,11-methane-epoxy Prostaglandin F_1α

Cayman Chemical Item Number 10007850

9,11-Epoxymethano PGH₁ (CAS 72517-81-8)

9,11-methane-epoxy Prostaglandin F1α (CAS 72517-81-8)

See more	Prostaglandins (517) Atherosclerosis (325) Vascular Disease (115)

Description

Prostaglandin (PG) endoperoxides are intermediates in the biosynthesis of PGs, thromboxanes, and prostacyclin. The endoperoxides, PGH₂ and PGG₂, induce rapid and irreversible aggregation of human platelets.¹ PGH₁ and PGG₁ are known to contract smooth muscle preparations, but are lacking in aggregatory effects. 9,11-methane-epoxy PGF_1α is a stable epoxymethano analog of PGH₁ that produces a strong and dose-related aggregation of washed rabbit platelets (EC₅₀ = 0.88 µM) and contraction of rabbit aortic strips (EC₅₀ = 0.11 µM).¹ 9,11-methane-epoxy PGF_1α induces contraction of guinea pig tracheas (EC₅₀ = 3.4 µM) with a maximal contraction of about 60% of that caused by a submaximal dose of histamine.

1 Morita, A., Nishino, H., Hasegawa, K., et al. Biological activities of prostaglandin H₁ analogs. Prostaglandins 18(4) 529-540 (1979).

Synonyms	9,11-Epoxymethano PGH1
Formal Name	6-(3-hydroxy-1-octenyl)-2-oxabicyclo[2.2.1]heptane-5-heptanoic acid
CAS Number	72517-81-8
Molecular Formula	C₂₁H₃₆O₄
Formula Weight	352.5
Formulation	A solution in methyl acetate
Purity	>96%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCC[C@H](O)/C=C/[C@H]1C2OCC(C2)[C@@H]1CCCCCCC(O)=O

Background Reading

Morita, A., Nishino, H., Hasegawa, K., et al. Biological activities of prostaglandin H₁ analogs. Prostaglandins 18(4) 529-540 (1979).

9,11-methane-epoxy Prostaglandin F1α is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
100 µg	$33.00		$0.00
500 µg	$149.00		$0.00
1 mg	$264.00		$0.00
5 mg	$1,155.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

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U-46619

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9,11-methane-epoxy Prostaglandin F1α