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Pargyline (hydrochloride)

Cayman Chemical Item Number 10007852

(CAS 306-07-0)

Pargyline (hydrochloride) (CAS 306-07-0)

See more	Endocrinology (335) Hypertension (90)

Description

Pargyline is an irreversible inhibitor of monoamine oxidase (MAO) that is used clinically to treat moderate hypertension.^1,2 At 10 mg/kg iv, pargyline induces a moderate decrease of systolic blood pressure in unanaesthetized hypertensive rats but not normotensive WKR or Sprague-Daley rats.³ The correlation between the fall of blood pressure and the inhibition of brain MAO suggests that the accumulation of amine in brain is responsible for the fall in pressure.⁴ Reactive oxygen species-mediated monocyte hypertrophy is prevented by pargyline at a concentration of 10 µM.¹

1 Bianchi, P., Pimentel, D.R., Murphy, M.P., et al. A new hypertrophic mechanism of serotonin in cardiac myocytes: Receptor-independent ROS generation. FASEB J 1-15 (2005).

2 Puig, M., Wakade, A.R., and Kirpekar, S.M. Effect of the sympathetic nervous system of chronic treatment with parglyline and l-DOPA. J Pharmacol Exp Ther 182(1) 130-134 (1972).

3 Fuentes, J.A., Ordaz, A., and Neff, N.H. Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive rats. Eur J Pharmacol 57 21-27 (1979).

4 Yamori, Y., De Jong, W., Yamabe, H., et al. Effects of L-dopa and inhibitors of decarboxylase and monoamine oxidase on brain noradrenaline leves and blood pressure in spontaneously hypertensive rats. J Pharm Pharmacol 24 690-695 (1972).

Formal Name	N-methyl-N-2-propynyl-benzenemethanamine, monohydrochloride
CAS Number	306-07-0
Molecular Formula	C₁₁H₁₃N · HCl
Formula Weight	195.7
Formulation	A crystalline solid
Purity	>98%
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CN(CC#C)CC1=CC=CC=C1.Cl

Background Reading

Bianchi, P., Pimentel, D.R., Murphy, M.P., et al. A new hypertrophic mechanism of serotonin in cardiac myocytes: Receptor-independent ROS generation. FASEB J 1-15 (2005).

Yamori, Y., De Jong, W., Yamabe, H., et al. Effects of L-dopa and inhibitors of decarboxylase and monoamine oxidase on brain noradrenaline leves and blood pressure in spontaneously hypertensive rats. J Pharm Pharmacol 24 690-695 (1972).

Fuentes, J.A., Ordaz, A., and Neff, N.H. Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive rats. Eur J Pharmacol 57 21-27 (1979).

Puig, M., Wakade, A.R., and Kirpekar, S.M. Effect of the sympathetic nervous system of chronic treatment with parglyline and l-DOPA. J Pharmacol Exp Ther 182(1) 130-134 (1972).

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Pargyline (hydrochloride) is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
100 mg	$6.00		$0.00
500 mg	$27.00		$0.00
1 g	$48.00		$0.00
5 g	$210.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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