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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Leukotriene E4-d5

Cayman Chemical Item Number 10007858

LTE4-D5

Leukotriene E4-d5

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Description

Leukotriene E4-d5 (LTE4-d5) contains five deuterium atoms at the 19, 19', 20, 20 and 20 positions. It is intended for use as an internal standard for the quantification of LTE4 by GC- or LC-mass spectrometry. LTE4 is produced by the action of dipeptidase on LTD4, leaving only the cysteinyl group still attached to the fatty acid backbone.1 It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A).2 LTE4 is considerably less active (8 to 12-fold) than LTC4 in the biological activities characteristic of cysteinyl leukotrienes.1,3 Unlike LTC4 and LTD4, LTE4 accumulates in both plasma and urine. Therefore, urinary excretion of LTE4 is most often used as an indicator of asthma.4,5,6 In humans, basal levels of LTE4 range from 1-100 pg/mg creatinine. In asthmatic patients, urinary LTE4 levels increase to 80-1,000 pg/mg creatinine.5

1 Bernström, K., and Hammarström, S. Metabolism of leukotriene D by porcine kidney. J Biol Chem 256 9579-9582 (1981).

2 Samuelsson, B. Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation. Science 220 568-575 (1983).

3 Lefer, A.M. Leukotrienes as mediators of ischemia and shock. Biochem Pharmacol 35 123-127 (1986).

4 Kumlin, M., Stensvad, F., Larsson, L., et al. Validation and application of a new simple strategy for measurements of urinary leukotriene E4 in humans. Clin Exp Allergy 25 467-479 (1995).

5 Drazen, J.M., O'Brien, J., Sparrow, D., et al. Recovery of leukotriene E4 from the urine of patients with airway obstruction. Am Rev Respir Dis 146 104-108 (1992).

6 Kumlin, M., Dahlén, B., Björck, T., et al. Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics. Am Rev Respir Dis 146 96-103 (1992).

Synonyms
  • LTE4-D5
Formal Name 5S-​hydroxy-​6R-​(S-​cysteinyl)-​7E,​9E,​11Z,​14Z-​eicosatetraenoic-​19,​19,​20,​20,​20-​d5 acid
Molecular Formula C23H32D5NO5S
Formula Weight 444.6
Formulation A solution in ethanol
Purity ≥99% deuterated product
λmax 281 nm
ε 40
Stability 1 year
Storage -80°C
Shipping Dry Ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C\C=C/C=C\C=C/C(SCC(N)​C(=O)​O)​[C@@H]​(O)​CCCC(=O)​O

Background Reading

Bernström, K., and Hammarström, S. Metabolism of leukotriene D by porcine kidney. J Biol Chem 256 9579-9582 (1981).

Samuelsson, B. Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation. Science 220 568-575 (1983).

Kumlin, M., Stensvad, F., Larsson, L., et al. Validation and application of a new simple strategy for measurements of urinary leukotriene E4 in humans. Clin Exp Allergy 25 467-479 (1995).

Kumlin, M., Dahlén, B., Björck, T., et al. Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics. Am Rev Respir Dis 146 96-103 (1992).

Drazen, J.M., O'Brien, J., Sparrow, D., et al. Recovery of leukotriene E4 from the urine of patients with airway obstruction. Am Rev Respir Dis 146 104-108 (1992).

Lefer, A.M. Leukotrienes as mediators of ischemia and shock. Biochem Pharmacol 35 123-127 (1986).

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Size Price Quantity Subtotal
25 µg $229.00 $0.00
50 µg $435.00 $0.00
100 µg $824.00 $0.00
500 µg $3,664.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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