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CAY10499 Exclusive

Cayman Chemical Item Number 10007875

(CAS 359714-55-9)

CAY10499 (CAS 359714-55-9)

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Description

Hormone sensitive lipase (HSL) catalyzes the hydrolysis of tri-, di-, and monoacylglycerols, as well as cholesterol esters, thus mobilizing fatty acids as a primary source of energy in mammals.1 The enzyme is highly expressed in adipose tissue and steroidogenic tissues, and less abundantly in skeletal muscle, heart, brain, pancreatic beta cells, adrenal gland, ovaries, testes, and macrophages. Its presence in various tissues indicates the enzyme plays diverse roles including those in steroidogenesis and spermatogenesis, foam cell formation in atherosclerosis, and diabetes.1,2 CAY10499 is a potent inhibitor of human HSL exhibiting an IC50 of 90 nM for the recombinant enzyme.3 The in vivo pharmacological efficacy of CAY10499 has not been reported.

1 Saltiel, A.R. Another hormone-sensitive triglyceride lipase in fat cells. Proc Natl Acad Sci USA 97(2) 535-537 (2000 Jan 18).

2 Kraemer, F.B., and Shen, W. Hormone-sensitive lipase: Control of intracellular tri-(di-)acylglycerol and cholesteryl ester hydrolysis. J Lipid Res 43 1585-1594 (2002 Jan 1).

3 Ali, Y.B., Müller, G., Petry, S., et al. Kinetic characterization and specific inhibition of hormone sensitive lipase. Abstracts for the 46th International Conference on the Bioscience of Lipids 136 (2005).

Formal Name [4-​(5-​methoxy-​2-​oxo-​1,​3,​4-​oxadiazol-​3(2H)-​yl)-​2-​methylphenyl]-​carbamic acid,​ phenylmethyl ester
CAS Number 359714-55-9
Molecular Formula C18H17N3O5
Formula Weight 355.3
Formulation A crystalline solid
Purity ≥98%
λmax 206, 256 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COc1nn(c2ccc(NC(=O)​OCc3ccccc3)​c(C)​c2)​c(=O)​o1

Background Reading

Saltiel, A.R. Another hormone-sensitive triglyceride lipase in fat cells. Proc Natl Acad Sci USA 97(2) 535-537 (2000 Jan 18).

Ali, Y.B., Müller, G., Petry, S., et al. Kinetic characterization and specific inhibition of hormone sensitive lipase. Abstracts for the 46th International Conference on the Bioscience of Lipids 136 (2005).

Kraemer, F.B., and Shen, W. Hormone-sensitive lipase: Control of intracellular tri-(di-)acylglycerol and cholesteryl ester hydrolysis. J Lipid Res 43 1585-1594 (2002 Jan 1).
Size Price Quantity Subtotal
1 mg $11.00 $0.00
5 mg $50.00 $0.00
10 mg $88.00 $0.00
25 mg $193.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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