Cayman Chemical | oxLDL-β2GPI (human) ELISA Kit | Description • Oxidized low-density lipoprotein-β2 Glycoprotein I (human) EIA kit

10007893 oxLDL-β₂GPI (human) ELISA Kit

Oxidized low-density lipoprotein-β₂ Glycoprotein I (human) EIA kit

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• See more Assay Kits; Atherosclerosis; Oxidative Injury

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Atherosclerosis is characterized by a gradual thickening of arterial walls due to the excessive accumulation of lipids. Oxidized low-density lipoprotein (oxLDL) is the principal form of cholesterol that accumulates in atherosclerotic lesions or plaques.^1,2 Unlike native LDL, oxLDL binds to β₂ glycoprotein I (β₂GPI) to form oxLDL-β₂GPI complexes. Stable oxLDL-β₂GPI complexes are regarded as pathogenic and appear to be highly clinically relevant.³ Cayman’s oxLDL-β₂GPI (human) ELISA is an immunometric (i.e., sandwich) assay that detects the circulating oxLDL-β₂GPI complex in human serum or plasma. The wells of each 96-well plate are coated with a monoclonal antibody against human β₂GPI. Bound oxLDL-β₂GPI is detected using a horseradish peroxidase (HRP)-labeled monoclonal antibody directed against human apoB100. Results are calculated against a standard curve prepared from the Reference Solution provided in the kit.

1 Ylä-Herttuala, S., Palinski, W., Rosenfeld, M.E., et al. Evidence for the presence of oxidatively modified low density lipoprotein in atheroscelrotic lesions of rabbit and man. J Clin Invest 84 1086-1095 (1989 Oct 11).

2 McMurray, H., Parthasarathy, S., Steinberg, D. Oxidatively modified low density lipoprotein is a chemoattractant for human T lymphocytes. J Clin Invest 92 1004-1008 (1993 Aug 1).

3 Matsuura, E., Kobayashi, K., Inoue, K., et al. Oxidized LDL/β₂-glycoprotein I complexes: New aspects in atherosclerosis. Lupus 14 736-741 (2005).

	Download Kit Booklet 706 Kb PDF
	Download Material Safety Data Sheet (MSDS) 96 Kb PDF
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	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm

Purchase 10007893 oxLDL-β₂GPI (human) ELISA Kit

Pricing is for North America only. Other customers should contact a distributor in their region.

Available to customers in North, South, and Central America only.

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Warning This product is not for human or veterinary use.

Pricing updated 2010-03-19.
Prices are subject to change without notice.