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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

20-carboxy Arachidonic Acid Exclusive

Cayman Chemical Item Number 10007912

20-COOH-AA (CAS 79551-84-1)

20-carboxy Arachidonic Acid (CAS 79551-84-1)

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Description

20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B.1 Like 20-HETE, 20-COOH-AA inhibits ion transport in the kidneys. It also produces vasorelaxation of porcine coronary microvessels constricted with endothelin. 20-COOH-AA binds to isolated ligand binding domains of peroxisome proliferator-activated receptor α (PPARα) (Kd = 0.87 ± 0.12 µM) and PPARγ (Kd = 1.7 ± 0.5 µM), and is a dual activator of PPARα and PPARγ in a transiently transfected COS-7 cell reporter system.1

1 Fang, X., Dillon, J.S., Hu, S., et al. 20-carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors α and γ. Prostaglandins Other Lipid Mediat 82 175-184 (2007).

Synonyms
  • 20-COOH-AA
Formal Name 5Z,​8Z,​11Z,​14Z-​eicosatetraenedioic acid
CAS Number 79551-84-1
Molecular Formula C20H30O4
Formula Weight 334.5
Formulation A solution in ethanol
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC(=O)​CCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)​O

Background Reading

Fang, X., Dillon, J.S., Hu, S., et al. 20-carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors α and γ. Prostaglandins Other Lipid Mediat 82 175-184 (2007).

20-carboxy Arachidonic Acid is available in the following screening library:

Size Price Quantity Subtotal
25 µg $183.00 $0.00
50 µg $348.00 $0.00
100 µg $659.00 $0.00
500 µg $2,928.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

20-HETE
Arachidonic Acid
Arachidonic Acid (sodium salt)

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