See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

Prostaglandin E Synthase-1 (microsomal) (human recombinant)

Cayman Chemical Item Number 10007939

Membrane-Associated PGES-1; Prostaglandin H/E Isomerase; PIG12; mPGE Synthase-1; MGST1-L1

See more

Description

Source: active recombinant enzyme isolated from a baculovirus overexpression system in Sf21 cells · Mr: ~21 kDa · Prostaglandin E synthases (PGESs) are enzymes that convert cyclooxygenase (COX)-derived PGH2 to PGE2.1 There are three different PGES enzymes with distinct enzymatic properties, modes of expression, cellular and subcellular localizations, and intracellular functions, two of which are membrane-bound enzymes and have been designated as mPGES-1 and mPGES-2. mPGES-1 is a perinuclear protein belonging to the membrane-associated proteins involved in eicosanoid and glutathione metabolism (MAPEG) superfamily.2 It requires glutathione as an essential cofactor for activity. mPGES-1 is up-regulated in response to various proinflammatory stimuli with a concomitant increased expression of COX-2 and is down-regulated by glucocorticoids.3 mPGES-1 gene knockout studies in mice have indicated a role for mPGES-1-generated PGE2 in female reproduction, inflammation, pain, fever, anorexia, atherosclerosis, stroke, and tumorigenesis. Therefore, mPGES-1 is a potential drug target for various diseases.1

1 Friesen, R.W., and Mancini, J.A. Microsomal prostaglandin E2 synthase-1 (mPGES-1): A novel anti-inflammatory therapeutic target. J Med Chem 51(14) 4059-4067 (2008).

2 Ouellet, M., Falgueyret, J., Ear, P.H., et al. Purification and characterization of recombinant microsomal prostaglandin E synthase-1. Protein Expr Purif 26 489-495 (2002).

3 Forsberg, L., Leeb, L., Thorén, S., et al. Human glutathione dependent prostaglandin E synthase: Gene structure and regulation. FEBS Lett 471 78-82 (2000).

Synonyms
  • Membrane-Associated PGES-1
  • Prostaglandin H/E Isomerase
  • PIG12
  • mPGE Synthase-1
  • MGST1-L1
Formulation A solution in 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride and 20% glycerol
Purity 16,000 x g supernatant
Stability 6 months
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere

Background Reading

Ouellet, M., Falgueyret, J., Ear, P.H., et al. Purification and characterization of recombinant microsomal prostaglandin E synthase-1. Protein Expr Purif 26 489-495 (2002).

Friesen, R.W., and Mancini, J.A. Microsomal prostaglandin E2 synthase-1 (mPGES-1): A novel anti-inflammatory therapeutic target. J Med Chem 51(14) 4059-4067 (2008).

Forsberg, L., Leeb, L., Thorén, S., et al. Human glutathione dependent prostaglandin E synthase: Gene structure and regulation. FEBS Lett 471 78-82 (2000).
Size Price Quantity Subtotal
250 units $105.00 $0.00
500 units $200.00 $0.00
1 Kunits $378.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Prostaglandin E Synthase-1 (microsomal) Monoclonal Antibody (Clone 6C6)
Prostaglandin E Synthase-1 (microsomal) Polyclonal Antibody

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?