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Prostaglandin E Synthase-1 (microsomal) (human recombinant)

Cayman Chemical Item Number 10007939

MGST1-L1; mPGE Synthase-1; PIG12; Prostaglandin H/E Isomerase; Membrane-Associated PGES-1

See more	Enzyme Activity (146) Eicosanoids (216) Enzymes (119) Prostaglandins (513) Proteins (180) Recombinant Proteins (171) Atherosclerosis (323) Cancer (606) Inflammation (383) Pain (144)

Description

Source: recombinant enzyme isolated from a baculovirus overexpression system in Sf21 cells · M_r: ~21 kDa · Prostaglandin E synthases (PGESs) are enzymes that convert cyclooxygenase (COX)-derived PGH₂ to PGE₂.¹ There are three different PGES enzymes with distinct enzymatic properties, modes of expression, cellular and subcellular localizations, and intracellular functions, two of which are membrane-bound enzymes and have been designated as mPGES-1 and mPGES-2. mPGES-1 is a perinuclear protein belonging to the membrane-associated proteins involved in eicosanoid and glutathione metabolism (MAPEG) superfamily.² It requires glutathione as an essential cofactor for activity. mPGES-1 is up-regulated in response to various proinflammatory stimuli with a concomitant increased expression of COX-2 and is down-regulated by glucocorticoids.³ mPGES-1 gene knockout studies in mice have indicated a role for mPGES-1-generated PGE₂ in female reproduction, inflammation, pain, fever, anorexia, atherosclerosis, stroke, and tumorigenesis. Therefore, mPGES-1 is a potential drug target for various diseases.¹

1 Friesen, R.W., and Mancini, J.A. Microsomal prostaglandin E₂ synthase-1 (mPGES-1): A novel anti-inflammatory therapeutic target. J Med Chem 51(14) 4059-4067 (2008).

2 Ouellet, M., Falgueyret, J., Ear, P.H., et al. Purification and characterization of recombinant microsomal prostaglandin E synthase-1. Protein Expr Purif 26 489-495 (2002).

3 Forsberg, L., Leeb, L., Thorén, S., et al. Human glutathione dependent prostaglandin E synthase: Gene structure and regulation. FEBS Lett 471 78-82 (2000).

Synonyms	MGST1-L1 mPGE Synthase-1 PIG12 Prostaglandin H/E Isomerase Membrane-Associated PGES-1
Formulation	A solution in 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride and 20% glycerol
Purity	16,000 x g supernatant
Stability	6 months
Storage	-80°C
Shipping	Dry ice in continental US; may vary elsewhere

Background Reading

Ouellet, M., Falgueyret, J., Ear, P.H., et al. Purification and characterization of recombinant microsomal prostaglandin E synthase-1. Protein Expr Purif 26 489-495 (2002).

Friesen, R.W., and Mancini, J.A. Microsomal prostaglandin E₂ synthase-1 (mPGES-1): A novel anti-inflammatory therapeutic target. J Med Chem 51(14) 4059-4067 (2008).

Forsberg, L., Leeb, L., Thorén, S., et al. Human glutathione dependent prostaglandin E synthase: Gene structure and regulation. FEBS Lett 471 78-82 (2000).

Size	Price	Quantity	Subtotal
250 units	$105.00		$0.00
500 units	$200.00		$0.00
1 Kunits	$378.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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