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CAY10498

Cayman Chemical Item Number 10007955

2-phenyl-amino-N6-endo-norbornyladenine (CAS 863202-33-9)

CAY10498 (CAS 863202-33-9)

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Description

The A1, A2A, A2B, and A3 adenosine receptors (ARs) are ubiquitous G protein-coupled receptors. The four AR subtypes have been implicated in several areas of therapeutic interest such as stroke and other ischemic conditions, as well as inflammation, neurodegenerative diseases, diabetes, and sleep regulation.1 A3 AR antagonists are of interest as therapeutic agents in glaucoma agents and inflammation. CAY10498 is a potent and selective A3 AR antagonist exhibiting a Ki of 37 nM with 60 and 200-fold selectivity over A1 and A2A adenosine receptors, respectively.1 CAY10498 is also a structural analog of reversine, a dedifferentiation agent of embryonic progenitor cells.2 However, no dedifferentiation effects or any connection between A3 AR antagonism and dedifferentiation have been demonstrated.

1 Perreira, M., Jiang, J., Klutz, A.M., et al. “Reversine” and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem 48 4910-4918 (2005).

2 Chen, S., Zhang, Q., Wu, X., et al. Dedifferentiation of lineage-committed cells by a small molecule. J Am Chem Soc 126 410-411 (2004).

Synonyms
  • 2-phenyl-amino-N6-endo-norbornyladenine
Formal Name 1H-​Purine-​2,​6-​diamine,​ N6-​(1R,​2S,​4S)-​bicyclo[2.2.1]hept-​2-​yl-​N2-​phenyl
CAS Number 863202-33-9
Molecular Formula C18H20N6
Formula Weight 320.4
Formulation A solution in ethanol
Purity ≥98%
λmax 257 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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c1ccc(cc1)​Nc1nc(NC2CC3CCC2C3)​c2nc[nH]​c2n1

Background Reading

Chen, S., Zhang, Q., Wu, X., et al. Dedifferentiation of lineage-committed cells by a small molecule. J Am Chem Soc 126 410-411 (2004).

Perreira, M., Jiang, J., Klutz, A.M., et al. “Reversine” and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem 48 4910-4918 (2005).

CAY10498 is available in the following screening library:

Size Price Quantity Subtotal
100 µg $23.00 $0.00
500 µg $104.00 $0.00
1 mg $184.00 $0.00
5 mg $805.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Purmorphamine
Retreversine
Reversine

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