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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

3,4-DAA

Cayman Chemical Item Number 10007980

3,4-DAA

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Description

Local catabolism of the amino acid tryptophan by indoleamine 2,3-dioxygenase (IDO) is considered an important mechanism of regulating T-cell immunity. Inhibition of the production of T helper-1 (TH1) cytokines offers a new strategy for treating TH1 mediated autoimmune diseases such as multiple sclerosis.3,4-DAA is an orally active synthetic derivative of the tryptophan metabolite anthranilic acid. It suppresses antigen-specific proliferation of MBP Ac1-11 TCR CD4+ T-cells. At a concentration of 200 µM, 3,4-DAA reduces IFN-γ, IL-2, IL-12/23 p40, and TNFα in splenocytes from antigen-induced transgenic mice. However, at a concentration of 30 µM, IL-4, and IL-10 levels were increased. Expression of inducible nitric oxide synthase and nitric oxide release from EOC20 cells induced by IFN-γ and LPS are also suppressed by 3,4-DAA at concentration of 30-200 µM. Mice with experimental autoimmune encephalomyelitis treated orally (300 mg/kg per day) with 3,4-DAA exhibited fewer and milder relapses and less severe disease compared to control animals.1

1 Platten, M., ho, P.P., Youssef, S., et al. Treatment of autoimmune neuroinflammation with a synthetic tyrptophan metabolite. Science 310 850-855 (2005).

Formal Name 2-​[3-​(3,​4-​dimethoxy-​phenyl)-​acryloylamino]-​3-​hydroxy-​benzoic acid
Molecular Formula C18H17NO6
Formula Weight 343.3
Formulation A crystalline solid
Purity ≥95%
λmax 347 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COc1ccc(\C=C/C(=O)​Nc2c(O)​cccc2C(=O)​O)​cc1OC

Background Reading

Platten, M., ho, P.P., Youssef, S., et al. Treatment of autoimmune neuroinflammation with a synthetic tyrptophan metabolite. Science 310 850-855 (2005).

3,4-DAA is available in the following screening library:

Size Price Quantity Subtotal
1 mg $13.00 $0.00
5 mg $59.00 $0.00
10 mg $104.00 $0.00
50 mg $455.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-10. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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