10008012  CAY10500
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• See below for pricing and ordering
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• See more Cytokines; Receptor Antagonist; Apoptosis; Drug Discovery; Inflammation

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Tumor necrosis factor α (TNFα) is a primary mediator of many inflammatory conditions including rheumatoid arthritis, toxic shock, and sepsis.1,2,3 TNFα functions as a trimer and promotes receptor trimerization to activate proinflammatory and/or apoptotic signalling pathways. 4,5 CAY10500 is an inhibitor of TNFα that prevents binding to the TNF Receptor 1 (TNFR1) with an IC50 of 22 µM.6 It binds to the biologically active TNFα trimer and promotes accelerated displacement of a single subunit to rapidly inactivate the cytokine. In a cell based assay, CAY10500 inhibited TNFα-mediated stimulation of IKB degradation with an IC50 of 4.6 µM.6
1  Beutler, B., Greenwald, D., Hulmes, J.D., et al. Identity of tumor necrosis factor and the macrophage-secreted factor cachectin. Nature 316 552-554 (1985).
2  missing reference text
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4  Thornberry, N.A., Lazebnik, Y. Caspases: Enemies within. Science 281 1312-1316 (1998).
5  missing reference text
6  He, M.M., Smith, A.S., Oslob, J.D., et al. Small-molecule inhibition of TNF-α Science 310, 1022-1025 (2005).


Purchase 10008012 CAY10500

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-12.
Prices are subject to change without notice.

Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.

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