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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

SPD-304 Exclusive

Cayman Chemical Item Number 10008012

(CAS 869998-49-2)

SPD-304 (CAS 869998-49-2)

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Description

Tumor necrosis factor α (TNFα) is a primary mediator of many inflammatory conditions including rheumatoid arthritis, toxic shock, and sepsis.1,2,3 TNFα functions as a trimer and promotes receptor trimerization to activate proinflammatory and/or apoptotic signalling pathways. 4,5 SPD-304 is an inhibitor of TNFα that prevents binding to the TNF Receptor 1 (TNFR1) with an IC50 of 22 µM.6 It binds to the biologically active TNFα trimer and promotes accelerated displacement of a single subunit to rapidly inactivate the cytokine. In a cell based assay, SPD-304 inhibited TNFα-mediated stimulation of IKB degradation with an IC50 of 4.6 µM.6

1 Beutler, B., Greenwald, D., Hulmes, J.D., et al. Identity of tumor necrosis factor and the macrophage-secreted factor cachectin. Nature 316 552-554 (1985).

2 missing reference text

3 missing reference text

4 Thornberry, N.A., and Lazebnik, Y. Caspases: Enemies within. Science 281 1312-1316 (1998).

5 missing reference text

6 He, M.M., Smith, A.S., Oslob, J.D., et al. Small-molecule inhibition of TNF-α. Science 310 1022-1025 (2005).

Formal Name 6,​7-​dimethyl-​3-​[[methyl[2-​[methyl[[1-​[3-​(trifluoromethyl)phenyl]-​1H-​indol-​3-​yl]methyl]amino]ethyl]amino]methyl]-​4H-​1-​benzopyran-​4-​one
CAS Number 869998-49-2
Molecular Formula C32H32F3N3O2
Formula Weight 547.6
Formulation A crystalline solid
Purity >98%
λmax 209, 252, 299 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CN(CCN(C)​Cc1cn(c2cccc(c2)​C(F)​(F)​F)​c2ccccc12)​Cc1coc2cc(C)​c(C)​cc2c1=O

Background Reading

He, M.M., Smith, A.S., Oslob, J.D., et al. Small-molecule inhibition of TNF-α. Science 310 1022-1025 (2005).
Size Price Quantity Subtotal
500 µg $23.00 $0.00
1 mg $44.00 $0.00
5 mg $184.00 $0.00
10 mg $322.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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