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ent-Prostaglandin F_2α

Cayman Chemical Item Number 10008122

(−)-Prostaglandin F_2α; ent-PGF_2α (CAS 54483-31-7)

ent-Prostaglandin F2α (CAS 54483-31-7)

See more	Isoprostanes (34) Prostaglandins (513) Oxidative Injury (258)

Description

Enzymatically-derived Prostaglandin F_2α (PGF_2α) is an optically pure compound whereas PGF_2α derived from the free radical-catalyzed peroxidation of arachidonate is a racemic mixture. Ent-PGF_2α is the opposite enantiomer of PGF_2α. This compound can only be generated via the isoprostane pathway of free radical-catalyzed lipid peroxidation and has been implicated as a marker of oxidative stress. Levels of ent-PGF_2α are elevated in human urine from heavy cigarette smokers and patients with hypercholesterolemia.¹

1 Yin, H., Gao, L., Tai, H., et al. Urinary prostaglandin F_2α is generated from the isoprostane pathway and not the cyclooxygenase in humans. J Biol Chem 282(1) 329-336 (2007).

Synonyms	(-)-Prostaglandin F2α ent-PGF2α
Formal Name	9β,11β,15R-trihydroxy-(8β,12α)-prosta-5Z,13E-dien-1-oic acid
CAS Number	54483-31-7
Molecular Formula	C₂₀H₃₄O₅
Formula Weight	354.5
Formulation	A solution in methyl acetate
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O[C@H]1[C@@H](C/C=C\CCCC(O)=O)[C@H](/C=C/[C@H](O)CCCCC)[C@@H](O)C1

Background Reading

Yin, H., Gao, L., Tai, H., et al. Urinary prostaglandin F_2α is generated from the isoprostane pathway and not the cyclooxygenase in humans. J Biol Chem 282(1) 329-336 (2007).

ent-Prostaglandin F2α is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$52.00		$0.00
5 mg	$234.00		$0.00
10 mg	$416.00		$0.00
50 mg	$1,820.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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ent-Prostaglandin F2α