|
10008128 10(S),17(S)-DiHDoHE
(CAS 871826-47-0)
10(S),17(S)-DiHDoHE Workbook Links
Cayman offers a variety of analysis tools to assist you.
Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.
|
Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities.1,2 10(S),17(S)-DiHDoHE is a DHA metabolite and protectin D1 analog that exhibits anti-inflammatory activity. It is produced by an apparent double lipoxygenase-mediated reaction in inflammatory exudates such as murine peritonitis and in suspensions of human leukocytes incubated with DHA.1 It differs from protectin D1 with respect to the stereochemistry of the C-10 hydroxyl and the double bond configuration at the 13 and 15 positions. 10(S),17(S)- DiHDoHE blocks neutrophil infiltration in murine peritonitis by 20-25% at a dose of 1 ng/mouse.1
|
|
1
Serhan, C.N., Gotlinger, K., Hong, S., et al. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: Assignments of dihydroxy-containing docosatrienes. J Immunol 176 1848-1859 (2006).
2
Ariel, A., Serhan, C.N. Resolvins and protectins in the termination program of acute inflammation. TRENDS in Immunology 28(4) 176-183 (2007).
|
Purchase 10008128 10(S),17(S)-DiHDoHE
Pricing is for North America only. Other customers should contact a distributor in their region.
This product is also available to buy in bulk quantities.
Please contact our
Sales Department
for a quote or to purchase.
Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services.
To ask for assistance with one of our products please contact our Technical Help staff.
Warning This product is not for human or veterinary use.
|
Pricing updated 2010-03-20.
Prices are subject to change without notice.
|
|
|
|
|
