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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

10(S),17(S)-DiHDoHE Exclusive

Cayman Chemical Item Number 10008128

PDX; Protectin DX (CAS 871826-47-0)

10(S),17(S)-DiHDoHE (CAS 871826-47-0)

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Description

Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities.1,2,3 10(S),17(S)-DiHDoHE is a DHA metabolite, also referred to as protectin DX (PDX).4 It is produced by an apparent double lipoxygenase (LO)-mediated reaction in murine peritonitis exudates, in suspensions of human leukocytes, or by soybean 15-LO incubated with DHA.1,4 It differs from protectin D1 with respect to the stereochemistry of the C-10 hydroxyl and the double bond configuration at the 13 and 15 positions. 10(S),17(S)-DiHDoHE blocks neutrophil infiltration in murine peritonitis by 20-25% at a dose of 1 ng/mouse.1 It also inhibits platelet activation by both impairing thromboxane (TX) synthesis and TX receptor activation.4,5

1 Serhan, C.N., Gotlinger, K., Hong, S., et al. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: Assignments of dihydroxy-containing docosatrienes. J Immunol 176 1848-1859 (2006).

2 Ariel, A., and Serhan, C.N. Resolvins and protectins in the termination program of acute inflammation. Trends Immunol 28(4) 176-183 (2007).

3 Schwab, J.M., Chiang, N., Arita, M., et al. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature 447 869-875 (2007).

4 Chen, P., Fenet, B., Michaud, S., et al. Full characterization of PDX, a neuroprotectin/protectin D1 isomer, which inhibits blood platelet aggregation. FEBS Lett 583 3478-84 (2009).

5 Chen, P., Véricel, E., Lagarde, M., et al. Poxytrins, a class of oxygenated products from polyunsaturated fatty acids, potently inhibit blood platelet aggregation. FASEB J 25 382-8 (2011).

Synonyms
  • PDX
  • Protectin DX
Formal Name 10(S),​17(S)-​dihydroxy-​4Z,​7Z,​11E,​13Z,​15E,​19Z-​docosahexaenoic acid
CAS Number 871826-47-0
Molecular Formula C22H32O4
Formula Weight 360.5
Formulation A solution in ethanol
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CC/C=C\CC(O)​\C=C\C=C\C=C/[C@@H]​(O)​C/C=C\C/C=C\CCC(=O)​O

Background Reading

Serhan, C.N., Gotlinger, K., Hong, S., et al. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: Assignments of dihydroxy-containing docosatrienes. J Immunol 176 1848-1859 (2006).

Ariel, A., and Serhan, C.N. Resolvins and protectins in the termination program of acute inflammation. Trends Immunol 28(4) 176-183 (2007).
Size Price Quantity Subtotal
25 µg $106.00 $0.00
50 µg $201.00 $0.00
100 µg $382.00 $0.00
500 µg $1,696.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

(±)19,20-DiHDPA
Docosahexaenoic Acid
Resolvin D2 Exclusive

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