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JNJ-10198409

Cayman Chemical Item Number 10008131

(CAS 627512-69-0)

JNJ-10198409 (CAS 627512-69-0)

See more	Receptor Biochemistry (59) Protein Kinase (7) Cancer (606) Signal Transduction (314)

Description

Inhibition of the tyrosine kinase activity of growth factor receptors such as the platelet-derived growth factor (PDGF-BB) receptor can have potent antiangiogenic and antiproliferative activity.¹ JNJ-10198409 is a small molecule inhibitor of PDGF-BB tyrosine kinase with an IC₅₀ value of 4.2 nM when tested in human coronary artery smooth muscle cells.² JNJ-10198409 is a competitive antagonist of the ATP binding and hydrolysis at this receptor, resulting in a dose dependent inhibition of tumor growth and angiogenesis.

1 Battegay, E.J., Rupp, J., Iruela-Arispe, L., et al. PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF β-receptors.. J Cell Biol 125(4) 917-928 (1994).

2 Ho, C.Y., Ludovici, D.W., Maharoof, U.S.M., et al. (6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: Platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells. J Med Chem 48 8163-8173 (2005).

Formal Name	N-(3-fluorophenyl)-2,4-dihydro-6,7-dimethoxy-indeno[1,2-c]pyrazol-3-amine
CAS Number	627512-69-0
Molecular Formula	C₁₈H₁₆FN₃O₂
Formula Weight	325.3
Formulation	A crystalline solid
Purity	≥98%
λ_max	267, 302 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard COc1cc2c(Cc3c(n[nH]c23)Nc2cccc(F)c2)cc1OC

Background Reading

Ho, C.Y., Ludovici, D.W., Maharoof, U.S.M., et al. (6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: Platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells. J Med Chem 48 8163-8173 (2005).

Battegay, E.J., Rupp, J., Iruela-Arispe, L., et al. PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF β-receptors.. J Cell Biol 125(4) 917-928 (1994).

JNJ-10198409 is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$21.00		$0.00
5 mg	$95.00		$0.00
10 mg	$168.00		$0.00
50 mg	$735.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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