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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

PtdIns-(4,5)-P2-biotin (sodium salt)

Cayman Chemical Item Number 10008159

Phosphatidylinositol-4,5-diphosphate C-8-biotin (sodium salt)

PtdIns-(4,5)-P2-biotin (sodium salt)

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Description

The PtdIns phosphates play an important role in the generation and transduction of intracellular signals.1 PtdIns-(4,5)-P2-biotin is an affinity probe which allows the PIP2 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(4,5)-P2 to serve as a general probe for any protein with a high affinity binding interaction with inositol-(4,5)-diphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.

1 Rückle, T., Schwarz, M.K., and Rommel, C. PI3Kγ inhibition: Towards an 'aspirin of the 21st century'? Nat Rev Drug Discov 5 903-918 (2006).

Synonyms
  • Phosphatidylinositol-4,5-diphosphate C-8-biotin (sodium salt)
Formal Name 1-​((1-​octanoyl-​N’-​biotinoyl-​1,​6-​diaminohexane-​2R-​octanoyl)phosphatidyl)inositol-​4,​5-​bisphosphate,​ trisodium salt
Molecular Formula C35H61N3O21P3S · 3Na
Formula Weight 1053.8
Formulation A lyophilized powder
Purity >98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O[C@@H]​1[C@@H]​(OP([O-]​)​(O)​=O)​[C@H]​(OP([O-]​)​(O)​=O)​[C@@H]​(O)​[C@@H]​(O)​[C@H]​1OP([O-]​)​(OCC(COC(CCCCCCCNC(CCCC[C@H]​2SC[C@@]​(N3[H]​)​([H]​)​[C@]​2([H]​)​N([H]​)​C3=O)​=O)​=O)​OC(CCCCCCC)​=O)​=O

Background Reading

Rückle, T., Schwarz, M.K., and Rommel, C. PI3Kγ inhibition: Towards an 'aspirin of the 21st century'? Nat Rev Drug Discov 5 903-918 (2006).
Size Price Quantity Subtotal
10 µg $141.00 $0.00
25 µg $317.00 $0.00
50 µg $564.00 $0.00
100 µg $846.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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