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Linolenic Acid ethyl ester

Cayman Chemical Item Number 10008199

Ethyl α-Linolenate; LAEE (CAS 1191-41-9)

Linolenic Acid ethyl ester (CAS 1191-41-9)

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Description

α-Linolenic acid (ALA) is an essential fatty acid found in leafy green vegetables. ALA, as part of a low saturated fat diet, helps prevent cardiovascular disease. ALA decreases blood pressure, serum cholesterol levels, and platelet aggregation.1 Linolenic acid ethyl ester (LAEE) is a neutral, more lipophilic form of the free acid that can be used as an exogenous source of α-linolenic acid. This ethanol metabolite may contribute to ethanol-induced hepatic fibrogenesis through stimulation of intracellular signaling pathways in hepatic stellate cells (HSC). LAEE increases cyclin E expression and CDK2 activity as well as increases ERK and JNK activity.2

1 Allman, M.A., Pena, M.M., and Pang, D. Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: Effects on platelet composition and function. Eur J Clin Nutr 49 169-178 (1995).

2 Li, J., Hu, W., Baldassare, J.J., et al. The ethanol metabolite, linolenic acid ethyl ester, stimulates mitogen-activated protein kinase and cyclin signaling in hepatic stellate cells. Life Sci 73 1083-1096 (2003).

Synonyms
  • Ethyl α-Linolenate
  • LAEE
Formal Name 9Z,​12Z,​15Z-​octadecatrienoic acid,​ ethyl ester
CAS Number 1191-41-9
Molecular Formula C20H34O2
Formula Weight 306.5
Formulation A solution in ethanol
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
CC/C=C\C/C=C\C/C=C\CCCCCCCC(OCC)​=O

Background Reading

Allman, M.A., Pena, M.M., and Pang, D. Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: Effects on platelet composition and function. Eur J Clin Nutr 49 169-178 (1995).

Li, J., Hu, W., Baldassare, J.J., et al. The ethanol metabolite, linolenic acid ethyl ester, stimulates mitogen-activated protein kinase and cyclin signaling in hepatic stellate cells. Life Sci 73 1083-1096 (2003).

Linolenic Acid ethyl ester is available in the following screening libraries:

Size Price Quantity Subtotal
50 mg $12.00 $0.00
100 mg $23.00 $0.00
500 mg $96.00 $0.00
1 g $168.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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