10008201  Oleic Acid ethyl ester

Ethyl Oleate (CAS 111-62-6)

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Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Oleic acid is a monounsaturated fatty acid and is one of the major components of membrane phospholipids. It contributes about 17% of the total fatty acids esterified to phosphatidylcholine in porcine platelets.1 Oleic acid ethyl ester is a neutral, more lipid-soluble form of oleic acid. As the free acid, it inhibits collagen-stimulated platelet aggregation by approximately 90% at a concentration of 10 µg/ml.1 It inhibits fMLF-induced neutrophil aggregation and degranulation by 55% and 68%, respectively, at 5 µM.2 Oleic acid, whether applied extracellularly (EC50 = ~60 µM) to human platelets or released from membrane phospholipids, causes an increase in intracellular calcium levels.3
1  Wahle, K.W.J., Peacock, L.I.L. Effects of isomeric cis and trans eighteen carbon monounsaturated fatty acids on porcine platelet function. Biochim Biophys Acta 1301 141-149 (1996).
2  Naccache, P.H., Moiski, T.F.P., Volpi, M., et al. Modulation of rabbit neutrophil aggregation and degranulation by free fatty acids. J Leukoc Biol 36 333-340 (1984).
3  Siafaka-Kapadai, A., Hanahan, D.J., Javors, M.A. Oleic acid-induced Ca2+ mobilization in human platelets: Is oleic acid an intracellular messenger?. J Lipid Mediat Cell Signal 15 215-232 (1997).


Purchase 10008201 Oleic Acid ethyl ester

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This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

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Warning This product is not for human or veterinary use.

Pricing updated 2010-03-13.
Prices are subject to change without notice.

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