Cayman Chemical | Palmitoleic Acid ethyl ester | Description • Ethyl Palmitoleate (CAS 56219-10-4)

10008204 Palmitoleic Acid ethyl ester

Ethyl Palmitoleate (CAS 56219-10-4)

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Palmitoleic acid (9-hexadecenoic acid) is an unsaturated fatty acid that is found in highest concentration in the liver. It is a common component of the glycerides of human adipose tissues. Two other sources of palmitoleic acid are macadamia oil and sea buckthorn oil which contain about 20% and 40% of total fatty acid composition, respectively.^1,2 Palmitoleic acid ethyl ester (ethyl palmitoleate) is a more lipophilic form of the free acid. It is one of the fatty acid ethyl esters that increase cytosolic Ca2+ concentration leading to pancreatic acinar cell injury due to excessive consumption of ethanol. Ethyl palmitoleate (10-100 µM) in addition to 850 mM ethanol resulted in sustained, concentration-dependent increases in Ca2+ that caused cell death.³ This fatty acid ethyl ester is also a potential biomarker for fetal exposure to alcohol.⁴

1 Yang, B., Kallio, H.P. Fatty acid composition of lipids in sea buckthorn (Hippophaë rhamnoids L.) berries of different origins. J Argic Food Chem 49 1939-1947 (2001).

2 Fard, A.M., Turner, A.G., Willett, G.D. High-resolution electrospray-ionization fourier-transform ion cyclotron resonance and gas chromatography-mass spectrometry of macadamia nut oil. Aust J Chem 56 499-508 (2003).

3 Criddle, D.N., Raraty, M.G.T., Neoptolemos, J.P., et al. Ethanol toxicity in pancreatic acinar cells: Mediation by nonoxidative fatty acid metabolites. Proc Natl Acad Sci USA 101(29) 10738-10743 (2004).

4 Moore, C., Jones, J., Lewis, D., et al. Prevalence of fatty acid ethyl esters in meconium specimens. Clin Chem 49(1) 133-136 (2003).

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Pricing updated 2010-03-19.
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