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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

N-acetyl-2-carboxy Benzenesulfonamide Exclusive

Cayman Chemical Item Number 10008284

(CAS 849067-18-1)

N-acetyl-2-carboxy Benzenesulfonamide (CAS 849067-18-1)

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Description

N-acetyl-2-carboxy Benzenesulfonamide is a is a structural analog of aspirin that acts as a non-selective inhibitor of cyclooxygenase (COX) with a COX-2 selectivity index of 0.23.1 In vitro studies showed that N-acetyl-2-carboxy Benzenesulfonamide is a more potent inhibitor of COX-1/COX-2 with IC50 values of 0.06 µM and 0.25 µM, respectively, than aspirin with IC50 values of 0.35 µM and 2.4 µM, respectively.

1 Chen, Q., Rao, P.N.P., and Knaus, E.E. Design, synthesis, and biological evaluation of N-acetyl-2-carboxybenzenesulfonamides: A novel class of cyclooxygenase-2 (COX-2) inhibitors. Bioorg Med Chem 13 2459-2468 (2005).

Formal Name 2-​[(acetylamino)sulfonyl]-​benzoic acid
CAS Number 849067-18-1
Molecular Formula C9H9NO5S
Formula Weight 243.2
Formulation A crystalline solid
Purity >98%
λmax 206, 224, 276 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CC(=O)​NS(=O)​(=O)​c1ccccc1C(=O)​O

Background Reading

Chen, Q., Rao, P.N.P., and Knaus, E.E. Design, synthesis, and biological evaluation of N-acetyl-2-carboxybenzenesulfonamides: A novel class of cyclooxygenase-2 (COX-2) inhibitors. Bioorg Med Chem 13 2459-2468 (2005).
Size Price Quantity Subtotal
1 mg $13.00 $0.00
5 mg $59.00 $0.00
10 mg $104.00 $0.00
50 mg $455.00 $0.00
Bulk Contact
Cart Total $0.00

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