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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

GW 610

Cayman Chemical Item Number 10008313

NSC 721648 (CAS 872726-44-8)

GW 610 (CAS 872726-44-8)

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Description

GW 610 is an antitumor benzothiazole that shows growth-inhibitory activity against several cancer cell lines. In MCF-7 and MDA 468 human cancer cell lines, potent antiproliferative activity (growth inhibition (GI50) < 0.1 nM) was observed.1 Potent and selective activity was also observed in the NCI 60 human cancer cell line panel. In contrast with previously reported 2-(4-aminophenyl)benzothiazoles, GW 610 is not reliant on induction of cytochrome P 1A1 (CYP1A1) expression for antitumor activity.

1 Mortimer, C.G., Wells, G., Crochard, J., et al. Antitumor benzothiazoles. 26. 2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines. J Med Chem 49 179-185 (2006).

Synonyms
  • NSC 721648
Formal Name 2-​(3,​4-​dimethoxyphenyl)-​5-​fluoro-​benzothiazole
CAS Number 872726-44-8
Molecular Formula C15H12FNO2S
Formula Weight 289.3
Formulation A crystalline solid
Purity ≥98%
λmax 223, 324 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COc1cc(ccc1OC)​c1nc2cc(F)​ccc2s1

Background Reading

Mortimer, C.G., Wells, G., Crochard, J., et al. Antitumor benzothiazoles. 26. 2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines. J Med Chem 49 179-185 (2006).

GW 610 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $17.00 $0.00
5 mg $77.00 $0.00
10 mg $136.00 $0.00
50 mg $595.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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