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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Gabapentin

Cayman Chemical Item Number 10008346

Neurontin® (CAS 60142-96-3)

Gabapentin (CAS 60142-96-3)

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Description

γ-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter that functions by binding to the GABA receptors located in the spinal cord.1 Gabapentin (Neurontin®) is a GABA analogue that acts as an anticonvulsant with proven analgesic effects in various neuropathic pain syndromes such as Complex Regional Pain Syndrome type one (CRPS 1).2,3,4 It is also prescribed to multiple sclerosis patients to control dysesthesias and may be useful in reducing neuropathic pain caused by cancer and HIV infection. It does not bind to GABA receptors, does not influence neural uptake of GABA, and does not inhibit the GABA-metabolizing enzyme, GABA transaminase.5,6 Unlike GABA, which does not pass through the blood-brain barrier, gabapentin penetrates into the central nervous system and binds to the α2δ-type voltage-gated calcium channels. The mechanism for the analgesic and anticonvulsant effects of gabapentin are not known.2,3,4,5,6

1 Malcangio, M., and Bowery, N.G. GABA and its receptors in the spinal cord. Trends Pharmacol Sci 17 457-462 (1996).

2 van de Vusse, A.C., Stonmp-van de Berg, S.G.M., Kessels, A.H.F., et al. Randomised controlled trial of gabapentin in complex regional pain syndrome type I [ISRCTN84121379]. BMC Neurol 4(13) (2004).

3 Hahn, K., Arendt, G., Braun, J.S., et al. A placebo-controlled trial of gabapentin for painful HIV-associated sendory neuropathies. J Neurol 251 1260-1266 (2004).

4 Caraceni, A., Zecca, E., Bonezzi, C., et al. Gabapentin for neuropathic cancer pain: A randomized controlled trial from the gabapentin cancer pain study group. J Clin Oncol 22(14) 2909-2917 (2004).

5 Gee, N.S., Brown, J.P., Dissanayake, V.U.K., et al. The novel anticonvulsant drug, gabapentin (neurontin), binds to the α2δ subunit of a calcium channel. J Biol Chem 271(10) 5768-5776 (1996).

6 Goa, K.L., and Sorkin, E.M. Gabapentin. A review of its pharmacological properties and clinical potential in epilepsy. Drugs 46(3) 409-427 (1993).

Synonyms
  • Neurontin®
Formal Name 1-​(aminomethyl)-​cyclohexaneacetic acid
CAS Number 60142-96-3
Molecular Formula C9H17NO2
Formula Weight 171.2
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
NCC1(CCCCC1)​CC(=O)​O

Background Reading

Malcangio, M., and Bowery, N.G. GABA and its receptors in the spinal cord. Trends Pharmacol Sci 17 457-462 (1996).

Hahn, K., Arendt, G., Braun, J.S., et al. A placebo-controlled trial of gabapentin for painful HIV-associated sendory neuropathies. J Neurol 251 1260-1266 (2004).

Gee, N.S., Brown, J.P., Dissanayake, V.U.K., et al. The novel anticonvulsant drug, gabapentin (neurontin), binds to the α2δ subunit of a calcium channel. J Biol Chem 271(10) 5768-5776 (1996).

Goa, K.L., and Sorkin, E.M. Gabapentin. A review of its pharmacological properties and clinical potential in epilepsy. Drugs 46(3) 409-427 (1993).

Caraceni, A., Zecca, E., Bonezzi, C., et al. Gabapentin for neuropathic cancer pain: A randomized controlled trial from the gabapentin cancer pain study group. J Clin Oncol 22(14) 2909-2917 (2004).

van de Vusse, A.C., Stonmp-van de Berg, S.G.M., Kessels, A.H.F., et al. Randomised controlled trial of gabapentin in complex regional pain syndrome type I [ISRCTN84121379]. BMC Neurol 4(13) (2004).

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Gabapentin is available in the following screening library:

Size Price Quantity Subtotal
10 mg $30.00 $0.00
25 mg $71.00 $0.00
50 mg $135.00 $0.00
100 mg $240.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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