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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

AL 8810 methyl ester

Cayman Chemical Item Number 10008370

AL 8810 methyl ester

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Description

AL 8810 is an 11β-fluoro analog of prostaglandin F2α (PGF2α) which acts as a potent and selective antagonist at the FP receptor.1 AL 8810 methyl ester is a lipid soluble, esterified prodrug form of AL 8810 analogous to the commonly used therapeutic intraocular PG compounds such as latanoprost2 and travoprost.3 The pharmacology of AL 8810 methyl ester has not been published.

1 Griffen, B.W., Klimko, P., Crider, J.Y., et al. AL-8810: A novel prostaglandin F2α analog with selective antagonist effects at the prostaglandin F2α (FP) receptor. J Pharmacol Exp Ther 290 1278-1284 (1999).

2 Camras, C.B., Alm, A., Watson, P., et al. Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patients. Ophthalmology 103 1916-1924 (1996).

3 Sorbera, L.A., and Castañer, J. Travoprost. Drugs Future 25 41-45 (2000).

Formal Name 9α,​15R-​dihydroxy-​11β-​fluoro-​15-​(2,​3-​dihydro-​1H-​inden-​2-​yl)-​16,​17,​18,​19,​20-​pentanor-​prosta-​5Z,​13E-​dien-​1-​oic acid,​ methyl ester
Molecular Formula C25H33FO4
Formula Weight 416.5
Formulation A crystalline solid
Purity >98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COC(=O)​CCC/C=C\CC1C(O)​C[C@H]​(F)​[C@@H]​1\C=C\[C@H]​(O)​C1Cc2ccccc2C1

Background Reading

Griffen, B.W., Klimko, P., Crider, J.Y., et al. AL-8810: A novel prostaglandin F2α analog with selective antagonist effects at the prostaglandin F2α (FP) receptor. J Pharmacol Exp Ther 290 1278-1284 (1999).

Camras, C.B., Alm, A., Watson, P., et al. Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patients. Ophthalmology 103 1916-1924 (1996).

Sorbera, L.A., and Castañer, J. Travoprost. Drugs Future 25 41-45 (2000).

AL 8810 methyl ester is available in the following screening library:

Size Price Quantity Subtotal
1 mg $54.00 $0.00
5 mg $243.00 $0.00
10 mg $432.00 $0.00
50 mg $1,890.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

AL 8810
AL 8810 ethyl amide
AL 8810 isopropyl ester
(S)-AL 8810
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