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α-Tocotrienol

Cayman Chemical Item Number 10008377

(CAS 58864-81-6)

α-Tocotrienol (CAS 58864-81-6)

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Description

The four tocopherols (α, β, δ, and γ) and four tocotrienols (α, β, δ, and γ) are forms of vitamin E, which is known for its antioxidant activity.1 Tocotrienols are found at high concentrations in palm oil and rice bran. Recent studies show tocotrienols may be more effective antioxidants than α-tocopherol, the most abundant form of vitamin E.2 Compared to other tocotrienols, α-tocotrienol exhibits the most potent neuroprotective actions in rat striatal neurons. At concentrations of 0.1-10 µM, α-tocotrienol significantly suppresses H2O2-induced cell death and provides protection against S-nitrocysteine-induced cell death and SIN-1 toxicity in a concentration dependent manner.2 HT4 cells, that are microinjected with 10−19 mol of α-tocotrienol into the cytosolic, are protected against glutamate-induced cell death by suppressing early activation of c-Src kinase and 12-lipoxygenase.3

1 Kamal-Eldin, A., and Appelqvist, L. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 31 671-701 (1996).

2 Osakada, F., Hashino, A., Kume, T., et al. α-Tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. Neuropharmacology 47 904-915 (2004).

3 Khanna, S., Roy, S., Slivka, S., et al. Neuroprotective properties of the natural vitamin E α-tocotrienol. Stroke 36 2258-2264 (2005).

Formal Name 3,​4-​dihydro-​2,​5,​7,​8-​tetramethyl-​2R-​[(3E,​7E)-​4,​8,​12-​trimethyl-​3,​7,​11-​tridecatrienyl)]-​2H-​1-​benzopyran-​6-​ol
CAS Number 58864-81-6
Molecular Formula C29H44O2
Formula Weight 424.7
Formulation A solution in ethanol
Purity ≥98%
λmax 289 nm
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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C[C@]​1(CC/C=C(C)​/CC/C=C(C)​/CC/C=C(C)​/C)​OC2=C(C)​C(C)​=C(O)​C(C)​=C2CC1

Background Reading

Osakada, F., Hashino, A., Kume, T., et al. α-Tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. Neuropharmacology 47 904-915 (2004).

Khanna, S., Roy, S., Slivka, S., et al. Neuroprotective properties of the natural vitamin E α-tocotrienol. Stroke 36 2258-2264 (2005).

Kamal-Eldin, A., and Appelqvist, L. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 31 671-701 (1996).

α-Tocotrienol is available in the following screening library:

Size Price Quantity Subtotal
1 mg $21.00 $0.00
5 mg $95.00 $0.00
10 mg $168.00 $0.00
25 mg $368.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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