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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Prostaglandin D2 methyl ester Exclusive

Cayman Chemical Item Number 10008385

PGD2 methyl ester (CAS 49852-81-5)

Prostaglandin D2 methyl ester (CAS 49852-81-5)

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Description

Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is produced in large quantities by hematopoietic PGD synthase during allergic and asthmatic anaphylaxis.1 It causes vasodilation, flushing, hypotension, and is an inhibitor of platelet aggregation.1,2 PGD2 is also produced in the brain via a soluble, secreted PGD-synthase also known as β-trace.3,4 In the brain, PGD2 produces normal physiological sleep and lowering of body temperature.3,4 PGD2 methyl ester is a more lipid-soluble, cell-permeable prodrug form of PGD2.5 It binds to the human and murine PGD2 receptors (DP1 and CRTH2/DP2) with 5-10 fold lower affinity than PGD2.6

1 Roberts, L.J., and Sweetman, B.J. Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosis. Prostaglandins 30 383-400 (1985).

2 Giles, H., and Leff, P. The biology and pharmacology of PGD2. Prostaglandins 35 277-300 (1988).

3 Hayaishi, O. Sleep-wake regulation by prostaglandins D2 and E2. J Biol Chem 263 14593-14596 (1988).

4 Onoe, H., Ueno, R., Fujita, I., et al. Prostaglandin D2, a cerebral sleep-inducing substance in monkeys. Proc Natl Acad Sci USA 85 4082-4086 (1988).

5 Suzuki, F., Hayashi, H., Ito, S., et al. Methyl ester of prostaglandin D2 as a delivery system of prostaglandin D2 into brain. Biochem Biophys Acta 917 224-230 (1987).

6 Hirai, H., Abe, H., Tanaka, K., et al. Gene structure and functional properties of mouse CRTH2, a prostaglandin D2 receptor. Biochem Biophys Res Commun 307 797-802 (2003).

Synonyms
  • PGD2 methyl ester
Formal Name 9α,​15S-​dihydroxy-​11-​oxo-​prosta-​5Z,​13E-​dien-​1-​oic acid,​ methyl ester
CAS Number 49852-81-5
Molecular Formula C21H34O5
Formula Weight 366.5
Formulation A solution in methyl acetate
Purity >97%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCCC(O)​/C=C/[C@H]​1C(=O)​CC(O)​C1C/C=C\CCCC(=O)​OC

Background Reading

Roberts, L.J., and Sweetman, B.J. Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosis. Prostaglandins 30 383-400 (1985).

Hayaishi, O. Sleep-wake regulation by prostaglandins D2 and E2. J Biol Chem 263 14593-14596 (1988).

Giles, H., and Leff, P. The biology and pharmacology of PGD2. Prostaglandins 35 277-300 (1988).

Onoe, H., Ueno, R., Fujita, I., et al. Prostaglandin D2, a cerebral sleep-inducing substance in monkeys. Proc Natl Acad Sci USA 85 4082-4086 (1988).

Hirai, H., Abe, H., Tanaka, K., et al. Gene structure and functional properties of mouse CRTH2, a prostaglandin D2 receptor. Biochem Biophys Res Commun 307 797-802 (2003).

Suzuki, F., Hayashi, H., Ito, S., et al. Methyl ester of prostaglandin D2 as a delivery system of prostaglandin D2 into brain. Biochem Biophys Acta 917 224-230 (1987).

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Prostaglandin D2 methyl ester is available in the following screening libraries:

Size Price Quantity Subtotal
500 µg $32.00 $0.00
1 mg $61.00 $0.00
5 mg $256.00 $0.00
10 mg $448.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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