PtdIns-(3,5)-P2 (1,2-dipalmitoyl) (sodium salt)

PtdIns-(3,5)-P₂ (1,2-dipalmitoyl) (sodium salt)

Cayman Chemical Item Number 10008398

Phosphatidylinositol-3,5-diphosphate C-16

Description

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.^1,2 PtdIns-(3,5)-P₂ (1,2-dipalmitoyl) (sodium salt) is a synthetic analog of natural PtdIns featuring saturated C₁₆:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol stereochemistry as that of the natural compound. PtdIns-(3,5)-P₂ is rapidly synthesized from PtdIns-(3)-P₁ in yeast when a PtdIns-(3)-P₅-hydroxy kinase is activated during hyperosmotic conditions.³ PtdIns-(3,5)-P₂ is also present in mammalian cells, such as monkey COS-7 cells, where a similar biosynthetic route has been demonstrated.³

1 Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36 481-509 (1996).

2 Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

3 Dove, S.K., Cooke, F.T., Douglas, M.R., et al. Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis. Nature 390 187-192 (1997).

Synonyms

Phosphatidylinositol-3,5-diphosphate C-16

Formal Name

1-(1,2R-dihexadecanoylphosphatidyl)inositol-3,5-bisphosphate, trisodium salt

Molecular Formula

C₄₁H₇₈O₁₉P₃ · 3Na

Formula Weight

1036.9

Formulation

A lyophilized powder

Purity

≥98%

Stability

1 year

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

SMILES

Copy SMILES to clipboard

O[C@@H]1[C@H](OP([O-])(O)=O)[C@@H](O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@@H]1OP([O-])(OC[C@H](OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)=O

Size

Price

Quantity

Subtotal

100 µg 
$48.00

$0.00

500 µg 
$216.00

$0.00

1 mg 
$384.00

$0.00

5 mg 
$1,680.00

$0.00

Bulk
Contact

Cart Total

$0.00

Other Resources

Management Team Company Profile Company History ChemAssistant Tools FAQs

Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases

Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule

Order Terms Browser Recommendation Privacy Statement Site Map

PtdIns-(3,5)-P₂ (1,2-dipalmitoyl) (sodium salt)