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PtdIns-(3,4)-P₂ (1,2-dioctanoyl) (sodium salt)

Cayman Chemical Item Number 10008400

Phosphatidylinositol-3,4-bisphosphate C-8 (sodium salt); DOPI-3,4-P₂ (sodium salt)

PtdIns-(3,4)-P2 (1,2-dioctanoyl) (sodium salt)

See more	Inositol Phosphates (78) Phospholipids (58) Cell Biology (281) Signal Transduction (314)

Description

The phosphatidylinositols (PtdIns) represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.^1,2 PtdIns-(3,4)-P₂-(1,2-dioctanoyl) is a synthetic analog of natural PtdIns featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound contains the same inositol and diacylglycerol (DAG) stereochemistry as the natural compound. The natural compound is the product of phosphorylation-dephosphorylation involving PtdIn 3-kinase and 5-phosphatases. The 3D-phosphorylated PtdIns are resistant to hydrolysis by phospholipase C.³

1 Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

2 Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36 481-509 (1996).

3 Serunian, L.A., Haber, M.T., Fukui, T., et al. Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipases C from rat liver and bovine brain. J Biol Chem 264(30) 17809-17815 (1989).

Synonyms	Phosphatidylinositol-3,4-bisphosphate C-8 (sodium salt) DOPI-3,4-P2 (sodium salt)
Formal Name	1-(1,2R-dioctanoylphosphatidyl)inositol-3,4-bisphosphate, trisodium salt
Molecular Formula	C₂₅H₄₆O₁₉P₃ · 3Na
Formula Weight	812.5
Formulation	A lyophilized powder
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O[C@H]1[C@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@@H](O)[C@@H](OP(OC[C@H](OC(CCCCCCC)=O)COC(CCCCCCC)=O)([O-])=O)[C@@H]1O

Background Reading

Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36 481-509 (1996).

Serunian, L.A., Haber, M.T., Fukui, T., et al. Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipases C from rat liver and bovine brain. J Biol Chem 264(30) 17809-17815 (1989).

Size	Price	Quantity	Subtotal
100 µg	$48.00		$0.00
500 µg	$216.00		$0.00
1 mg	$384.00		$0.00
5 mg	$1,680.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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PtdIns-(3,4)-P2 (1,2-dioctanoyl) (sodium salt)

PtdIns-(3,4)-P2 (1,2-dioctanoyl) (sodium salt)

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PtdIns-(3,4)-P₂ (1,2-dioctanoyl) (sodium salt)