D-myo-Inositol-4,5-diphosphate (sodium salt)

Cayman Chemical Item Number 10008418

Ins(4,5)-P₂ (sodium salt); 4,5-IP₂ (sodium salt)

Description

D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)P₃) is a key second messenger produced in cells by PLC-mediated hydrolysis of phosphatidylinositol-4,5-diphosphate.^1,2 Binding of Ins(1,4,5)P₃ to one of several Ins(1,4,5)P₃ receptors results in opening of the calcium channels and an increase in intracellular calcium.^2,3 Ins(4,5)P₂ is a metabolite of Ins(1,4,5)P₃ that lacks a phosphate at the 1' position. Ins(4,5)P₂ formation has been reported as an intermediate in the metabolism Ins(1,4,5)P₃ in GH3 pituitary cells.⁴

1 Streb, H., Irvine, R.F., Berridge, M.J., et al. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 306 67-69 (1983).

2 Yoshida, Y., and Imai, S. Structure and function of inositol 1,4,5-triphosphate receptor. Jpn J Pharmacol 74 125-137 (1997).

3 Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36 481-509 (1996).

4 Ruiz-Larrea, F., and Drummond, A.H. Pathways of dephosphorylation of 1-D-myo-inositol 1,4,5-trisphosphate in GH3 pituitary tumor cells. Biochem Biophys Acta 1178 63-72 (1993).

Synonyms

Ins(4,5)-P2 (sodium salt)
4,5-IP2 (sodium salt)

Formal Name

D-myo-inositol-4,5-di(hydrogen phosphate), disodium salt

Molecular Formula

C₆H₁₂O₁₂P₂ · 2Na

Formula Weight

384.1

Formulation

A lyophilized powder

Purity

≥98%

Stability

1 year

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

SMILES

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O[C@@H]1[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@@H](O)[C@H]1O.[Na+].[Na+]

Background Reading

Streb, H., Irvine, R.F., Berridge, M.J., et al. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 306 67-69 (1983).

Yoshida, Y., and Imai, S. Structure and function of inositol 1,4,5-triphosphate receptor. Jpn J Pharmacol 74 125-137 (1997).

Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36 481-509 (1996).

Ruiz-Larrea, F., and Drummond, A.H. Pathways of dephosphorylation of 1-D-myo-inositol 1,4,5-trisphosphate in GH3 pituitary tumor cells. Biochem Biophys Acta 1178 63-72 (1993).

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100 µg 
$39.00

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500 µg 
$176.00

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1 mg 
$312.00

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5 mg 
$1,365.00

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D-myo-Inositol-4,5-diphosphate (sodium salt)