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D-myo-Inositol-1,3-diphosphate (sodium salt)

Cayman Chemical Item Number 10008443

Ins(1,3)-P2 (sodium salt); 1,3-IP2 (sodium salt) (CAS 208584-52-5)

D-myo-Inositol-1,3-diphosphate (sodium salt) (CAS 208584-52-5)

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Description

D-myo-Inositol-1,3-phosphate (Ins(1,3)P) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals.1,2 The most studied InsP, Ins(1,4,5)P3 is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate.3,4 Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium.4,5 Ins(1,3)P2 can be dephosphorylated to Ins(1)P by inositol polyphosphate 3-phosphatase and further dephosphorylated to inositol by inositol monophosphatase.2

1 Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361 315-325 (1993).

2 Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

3 Streb, H., Irvine, R.F., Berridge, M.J., et al. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 306 67-69 (1983).

4 Yoshida, Y., and Imai, S. Structure and function of inositol 1,4,5-triphosphate receptor. Jpn J Pharmacol 74 125-137 (1997).

5 Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36 481-509 (1996).

Synonyms
  • Ins(1,3)-P2 (sodium salt)
  • 1,3-IP2 (sodium salt)
Formal Name D-​myo-​inositol-​1,​3-​bis(dihydrogen phosphate),​ disodium salt
CAS Number 208584-52-5
Molecular Formula C6H14O12P2 · 2Na
Formula Weight 386.1
Formulation A lyophilized powder
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O[C@H]​1[C@H]​(O)​[C@@H]​(OP([O-]​)​(O)​=O)​[C@@H]​(O)​[C@@H]​(OP([O-]​)​(O)​=O)​[C@@H]​1O.[Na+]​.[Na+]​

Background Reading

Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361 315-325 (1993).

Streb, H., Irvine, R.F., Berridge, M.J., et al. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 306 67-69 (1983).

Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

Yoshida, Y., and Imai, S. Structure and function of inositol 1,4,5-triphosphate receptor. Jpn J Pharmacol 74 125-137 (1997).

Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36 481-509 (1996).

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D-myo-Inositol-1,3-diphosphate (sodium salt) is available in the following screening library:

Size Price Quantity Subtotal
100 µg $39.00 $0.00
500 µg $176.00 $0.00
1 mg $312.00 $0.00
5 mg $1,365.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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