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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

D-myo-Inositol-1,2,5,6-tetraphosphate (sodium salt)

Cayman Chemical Item Number 10008444

1,2,5,6-IP4 (sodium salt); Ins(1,2,5,6)P4 (sodium salt)

D-myo-Inositol-1,2,5,6-tetraphosphate (sodium salt)

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Description

D-myo-Inositol-1,2,5,6-tetraphosphate (Ins(1,2,5,6)P4) is one of the many inositol phosphate isomers that act as small, soluble second messengers in the transmission of cellular signals.1,2,3. Ins(1,2,5,6)P4 binds to the murine Grp-1 PH domain with a Kd(apparent) of 0.18 µM, which is about 6.7-fold higher than for Ins(1,3,4,5)P4.4 It binds to rat heart membranes and significantly decreases heart rate in a pithed rat model.5

1 Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361 315-325 (1993).

2 Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

3 Shears, S.B. The versatility of inositol phosphates as cellular signals. Biochim Biophys Acta 1436 49-67 (1998).

4 Kavran, J.M., Klein, D.E., Lee, A., et al. Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains. J Biol Chem 273(46) 30497-30508 (1998).

5 Sun, X.X., Edvinsson, L., Yoo, H., et al. Effects of some novel D-myo-inositol-phosphate derivatives on binding and sympathetic transmission. J Cardiovasc Pharmacol 25 696-704 (1995).

Synonyms
  • 1,2,5,6-IP4 (sodium salt)
  • Ins(1,2,5,6)P4 (sodium salt)
Formal Name D-​myo-​inositol-​1,​2,​5,​6-​tetra(dihydrogen phosphate),​ tetrasodium salt
Molecular Formula C6H12O18P4· 4Na
Formula Weight 588.0
Formulation A lyophilized powder
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O[C@H]​1C(OP(=O)​(O)​O)​C(OP(=O)​(O)​O)​C(OP(=O)​(O)​O)​[C@@H]​(OP(=O)​(O)​O)​C1O

Background Reading

Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361 315-325 (1993).

Shears, S.B. The versatility of inositol phosphates as cellular signals. Biochim Biophys Acta 1436 49-67 (1998).

Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

Sun, X.X., Edvinsson, L., Yoo, H., et al. Effects of some novel D-myo-inositol-phosphate derivatives on binding and sympathetic transmission. J Cardiovasc Pharmacol 25 696-704 (1995).

Kavran, J.M., Klein, D.E., Lee, A., et al. Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains. J Biol Chem 273(46) 30497-30508 (1998).

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Size Price Quantity Subtotal
100 µg $110.00 $0.00
500 µg $495.00 $0.00
1 mg $880.00 $0.00
5 mg $3,850.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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