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3-methoxy Limaprost

Cayman Chemical Item Number 10008445

3-methoxy-2,3-dihydro-Limaprost; 3-methoxy-17α,20-dimethyl-Δ2-Prostaglandin E1

3-methoxy Limaprost

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Description

Limaprost is an analog of prostaglandin E1 (PGE1) with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is an inhibitor of ADP and collagen-induced platelet aggregation and is 10-1,000 times more potent than PGE1 as an inhibitor of platelet adhesiveness measured in vitro.1 3-methoxy Limaprost results from the Michael addition of methanol to the limaprost 2,3 double bond. The resulting novel compound is likely to retain FP receptor agonist activity; however there are no published studies of the pharmacological properties of 3-methoxy limaprost.

1 Tsuboi, T., Hatano, N., Nakatsuji, K., et al. Pharmacological evaluation of OP 1206, a prostaglandin E1 derivative, as an antianginal agent. Arch Int Pharmacodyn 247 89-102 (1980).

Synonyms
  • 3-methoxy-2,3-dihydro-Limaprost
  • 3-methoxy-17α,20-dimethyl-Δ2-Prostaglandin E1
Formal Name 3-​methoxy-​11α,​15S-​dihydroxy-​17S,​20-​dimethyl-​9-​oxo-​prosta-​13E-​en-​1-​oic acid
Molecular Formula C23H40O6
Formula Weight 412.6
Formulation A solution in methyl acetate
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCC(C)​CC(O)​/C=C/[C@H]​1C(O)​CC(=O)​C1CCCCC(OC)​CC(=O)​O

Background Reading

Tsuboi, T., Hatano, N., Nakatsuji, K., et al. Pharmacological evaluation of OP 1206, a prostaglandin E1 derivative, as an antianginal agent. Arch Int Pharmacodyn 247 89-102 (1980).

3-methoxy Limaprost is available in the following screening libraries:

Size Price Quantity Subtotal
500 µg $43.00 $0.00
1 mg $82.00 $0.00
5 mg $344.00 $0.00
10 mg $602.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Limaprost
Prostaglandin E1

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