10008463  ApoAI Polyclonal Antibody

Apolipoprotein A-I; Apolipoprotein AI

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• See more Immunocytochemistry; Western Blot; Antibodies; Atherosclerosis; Endocrinology; Inflammation; Nutrition/Diet

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Antigen: human ApoA1 protein amino acids 188-199 (RLAEYHAKTEH) · Host: rabbit · Application(s): WB and ICC; other applications not tested · ApoA1 is a major protein component in high-density lipoproteins (HDL). It acts as an acceptor for sequential transfers of phospholipids and free cholesterol from peripheral tissues as well as transporting cholesterol to the liver and other tissues for excretion and steroidogenesis.1 Serum ApoA1 levels are inversely related to the risk of developing atherosclerosis.2 Loss-of-function mutations in ApoA1 are causes of diseases such as HDL deficiency type 1 (or Tangier disease) and type 2 (familial hypoalphalipoproteinemia), and systemic non-neuropathic amyloidosis.3,4 Liver and small intestine are two main sources of the protein. ApoA1 is comprised of a single polypeptide chain of 243 amino acid residues with an estimated molecular weight of 28 kDa. Cayman’s ApoA1 polyclonal antibody detects the protein by western blot analysis in tissue/cell samples such as liver, intestine, and Hep-G2 cells. The antibody can also be used for immunocytochemistry.
1  Ajees, A.A., Anantharamaiah, G.M., Mishra, V.K., et al. Crystal structure of human apolipoprotein A-I: Insights into its protective effect against cardiovascular diseases. Proc Natl Acad Sci USA 103(7) 2126-2131 (2006).
2  Haas, M.J., Reinacher, D., Li, J.P., et al. Regulation of apoA1 gene expression with acidosis: Requirement for a transcriptional repressor. J Mol Endocrinol 27 43-57 (2001).
3  Tall, A.R., Wang, N. Tangier disease as a test of the reverse cholesterol transport hypothesis. J Clin Invest 106(10) 1205-1207 (2000).
4  Cheung, M.C., Mendez, A.J., Wolf, A.C., et al. Characterization of apolipoprotein A-I- and A-II-containing lipoproteins in a new case of high density lipoprotein deficiency resembling tangier disease and their effects on intracellular cholesterol efflux. J Clin Invest 91 522-529 (1993).


Purchase 10008463 ApoAI Polyclonal Antibody

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-12.
Prices are subject to change without notice.

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