Adipose Triglyceride Lipase Blocking Peptide

Cayman Chemical Item Number 10008492

ATGL; TG-hydrolase inducible PLA₂-ζ; Desnutrin

Description

Peptide sequence: human adipose triglyceride lipase (ATGL) protein amino acids 382-400 (KRKLGRHLPSRLPEQVELR) · To be used in conjunction with Cayman’s Adipose Triglyceride Lipase polyclonal antibody (Catalog No. 10006409) to block protein-antibody complex formation during immunochemical analysis of adipose triglyceride lipase protein. · Triglycerides are the most efficient form of energy storage in mammalian adipose tissue during times of caloric excess. ATGL is one of the key enzymes involved in the mobilization of fatty acids from triglyceride stores in adipose tissue, catalyzing the conversion of triacylglycerols to diacylglycerols.¹ Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity, and thus may be a potential drug target for the diabetic pathology.¹ ATGL mRNA is detected in a wide range of tissues including adipose, lung, skeletal muscle, testis, heart, brain, and kidney, with adipose tissue expressing the highest level.² Human ATGL is 504 amino acids in length with an estimated molecular weight of 55.2 kDa. Cayman’s ATGL polyclonal antibody detects the enzyme at 56 kDa by western blot from tissues and cells such as brown fat, liver, murine macrophages, and Hep-G₂ cells.

1 Zimmermann, R., Strauss, J.G., Haemmerle, G., et al. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 306 1383-1386 (2004).

2 Villena, J.A., Roy, S., Sarkadi-Nagy, E., et al. Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids. Ectopic expression of desnutrin increases triglyceride hydrolysis. J Biol Chem 279(45) 47066-47075 (2004).

Synonyms

ATGL
TG-hydrolase inducible PLA2-ζ
Desnutrin

Formulation

200 µg of peptide in 200 µl TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide

Stability

2 years

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Background Reading

Zimmermann, R., Strauss, J.G., Haemmerle, G., et al. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 306 1383-1386 (2004).

Villena, J.A., Roy, S., Sarkadi-Nagy, E., et al. Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids. Ectopic expression of desnutrin increases triglyceride hydrolysis. J Biol Chem 279(45) 47066-47075 (2004).

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