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15(R)-Pinane Thromboxane A2

Cayman Chemical Item Number 10008510

15(R)-PTA2

15(R)-Pinane Thromboxane A2

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Description

Pinane Thromboxane A2 (PTA2) is a stable analog of thromboxane A2 (TXA2). It is a thromboxane (TP) receptor antagonist and an inhibitor of thromboxane synthase.1,2 PTA2 inhibits U-46619-induced cat coronary artery constriction (IC50 = 0.1 µM), U-46619-induced aggregation of human platelets (IC50 = 2 µM), and rabbit platelet thromboxane synthase (IC50 = 50 µM). PTA2 does not affect prostaglandin I (PGI) synthase up to a concentration of 100 µM.1 15(R)-PTA2 is the 15-epimer of PTA2. There on no published reports on the formation or biological activity of 15(R)-PTA2.

1 Nicolaou, K.C., Magolda, R.L., Smith, J.B., et al. Synthesis and biological properties of pinane-thromboxane A2, a selective inhibitor of coronary artery constriction, platelet aggregation, and thromboxane formation. Proc Natl Acad Sci USA 76 2566-2570 (1979).

2 Schrör, K., Smith, E.F., Bickerton, M., et al. Preservation of ischemic myocardium by pinane thromboxane A2. Am J Physiol 238 H87-H92 (1980).

Synonyms
  • 15(R)-PTA2
Formal Name 9α,​11α-​(dimethyl)methylene-​15R-​hydroxy-​11a-​deoxy-​11a-​methylene-​thromba-​5Z,​13E-​dien-​1-​oic
Molecular Formula C24H40O3
Formula Weight 376.6
Formulation A solution in ethanol
Purity >98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC[C@@H]​(O)​/C=C/[C@H]​1C[C@H]​2C[C@H]​(C2(C)​C)​[C@@H]​1C/C=C\CCCC(O)​=O

Background Reading

Nicolaou, K.C., Magolda, R.L., Smith, J.B., et al. Synthesis and biological properties of pinane-thromboxane A2, a selective inhibitor of coronary artery constriction, platelet aggregation, and thromboxane formation. Proc Natl Acad Sci USA 76 2566-2570 (1979).

Schrör, K., Smith, E.F., Bickerton, M., et al. Preservation of ischemic myocardium by pinane thromboxane A2. Am J Physiol 238 H87-H92 (1980).

15(R)-Pinane Thromboxane A2 is available in the following screening libraries:

Size Price Quantity Subtotal
500 µg $43.00 $0.00
1 mg $82.00 $0.00
5 mg $344.00 $0.00
10 mg $602.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Pinane Thromboxane A2

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