Cayman Chemical | 8-iso-15-keto Prostaglandin F2β

10008539 8-iso-15-keto Prostaglandin F_2β

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8-iso Prostaglandin F_2β (8-iso PGF_2β) is an isomer of PGF_2α of non-enzymatic origin. It is one of 64 possible isomers of PGF_2α which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF_2β exhibits very weak contraction of human umbilical vein artery and does not promote aggregation of human whole blood.^1,2 However, 8-iso PGF_2β moderately contracts both the canine and porcine pulmonary vein, although the effect is much weaker than that exhibited by other isoprostanes such as 8-iso PGE₁, 8-iso PGE₂, or 8-iso PGF_2α.^3,4 8-iso-15-keto PGF_2β is a potential metabolite of 8-iso PGF_2β via the 15-hydroxy PG dehydrogenase pathway. There are no published reports on the formation or biological activity of 8-iso-15-keto PGF_2β.

1 Oliveira, L., Stallwood, N.A., Crankshaw, D.J. Effects of some isoprostanes on the human umbilical artery in vitro. Br J Pharmacol 129 509-514 (2000).

2 Cranshaw, J.H., Evans, T.W., Mitchell, J.A. Charcterization of the effects of isoprostanes on platelet aggregation in human whole blood. Br J Pharmacol 132 1699-1706 (2001).

3 Janssen, L.J., Premji, M., Netherton, S., et al. Vasoconstrictor actions of isoprostanes via tyrosine kinase and Rho kinase in human and canine pulmonary vascular smooth muscles. Br J Pharmacol 132 127-134 (2001).

4 Janssen, L.J., Tazzeo, T. Involvement of TP and EP₃ receptors in vasoconstrictor responses to isoprostanes in pulmonary vasculature. J Pharmacol Exp Ther 301(3) 1060-1066 (2002).

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Pricing updated 2010-03-14.
Prices are subject to change without notice.

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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.