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Epoxy Fluor 7 Exclusive

Cayman Chemical Item Number 10008610

(CAS 863223-43-2)

Epoxy Fluor 7 (CAS 863223-43-2)

See more	Enzyme Activity (146) Fluorescence (90) Enzyme Substrates (8) Endocrinology (335) Hypertension (90) Inflammation (383)

Description

Soluble epoxide hydrolase (sEH) catalyzes the conversion of epoxyeicosatrienoic acids (EpETrEs) to the corresponding DiHETrEs thereby diminishing their vasodilator activity.¹ Inhibitors of sEH may therefore have clinical utility for treating hypertension and systemic inflammation.^2,3 Epoxy fluor 7 is a sensitive fluorescent substrate for sEH that can be used to monitor the activity of both human and murine enzymes.⁴ Hydrolysis of the substrate epoxide yields a highly fluorescent product that can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. Epoxy fluor 7 is more stable in aqueous solution and offers about 2-fold better sensitivity than previously used colorimetric substrates such as NEPC.⁴

1 Yu, Z., Xu, F., Huse, L.M., et al. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circ Res 87 992-998 (2000).

2 Imig, J.D., Zhao, X., Zaharis, C.Z., et al. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Hypertension 46(2) 975-981 (2005).

3 Schmelzer, K.R., Kubala, L., Newman, J.W., et al. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Proc Natl Acad Sci USA 102(28) 9772-9777 (2005).

4 Jones, P.D., Wolf, N.M., Morisseau, C., et al. Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies. Anal Biochem 343 66-75 (2005).

Formal Name	cyano(6-methoxy-2-napthalenyl)methyl[(2,3)-3-phenyloxiranyl]methyl ester, carbonic acid
CAS Number	863223-43-2
Molecular Formula	C₂₃H₁₉NO₅
Formula Weight	389.4
Formulation	A crystalline solid
Purity	≥98%
λ_max	234 nm
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard COc1ccc2cc(ccc2c1)C(CN)OC(=O)OCC1OC1c1ccccc1

Background Reading

Jones, P.D., Wolf, N.M., Morisseau, C., et al. Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies. Anal Biochem 343 66-75 (2005).

Imig, J.D., Zhao, X., Zaharis, C.Z., et al. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Hypertension 46(2) 975-981 (2005).

Schmelzer, K.R., Kubala, L., Newman, J.W., et al. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Proc Natl Acad Sci USA 102(28) 9772-9777 (2005).

Yu, Z., Xu, F., Huse, L.M., et al. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circ Res 87 992-998 (2000).

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Epoxy Fluor 7 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$36.00		$0.00
5 mg	$162.00		$0.00
10 mg	$288.00		$0.00
50 mg	$1,260.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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