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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

GW 7647

Cayman Chemical Item Number 10008613

(CAS 265129-71-3)

GW 7647 (CAS 265129-71-3)

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Description

Peroxisome proliferator-activated receptor-α (PPARα) is a ligand-activated transcription factor involved in the regulation of lipid homeostasis.1,2 Activation of PPARα results in expression of a variety of genes, particularly those involved in fatty acid β-oxidation, binding, and transport.3 GW 7647 is a potent, selective agonist of human and murine PPARα4 It activates human PPARα, PPARγ, and PPARδ with EC50 values of 0.006, 1.1 and 6.2 µM, respectively, in a GAL4-PPAR binding assay. Similar EC50 values of 0.001, 1.3, and 2.9 were observed with the murine receptors. GW 7647 lowered triglycerides 93% and 60% in fat-fed hamsters and rats, respectively, at a dose of 3 mg/kg.4

1 Latruffe, N., and Vamecq, J. Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism. Biochimie 79 81-94 (1997).

2 Lemberger, T., Desvergne, B., and Wahli, W. Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology. Annu Rev Cell Dev Biol 12 335-363 (1996).

3 Mandard, S., Müller, M., and Kersten, S. Peroxisome proliferator-activated receptor α target genes. Cell Mol Life Sci 61 393-416 (2004).

4 Brown, P.J., Stuart, L.W., Hurley, K.P., et al. Identification of a subtype selective human PPARα agonist through parallel-array synthesis. Bioorg Med Chem Lett 11 1225-1227 (2001).

Formal Name 2-​methyl-​2-​[[4-​[2-​[[(cyclohexylamino)carbonyl](4-​cyclohexylbutyl)amino]ethyl]phenyl]thio]-​propanoic acid
CAS Number 265129-71-3
Molecular Formula C29H46N2O3S
Formula Weight 502.8
Formulation A crystalline solid
Purity ≥98%
λmax 230 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C(NC1CCCCC1)​N(CCCCC1CCCCC1)​CCc1ccc(cc1)​SC(C)​(C)​C(=O)​O

Background Reading

Honn, K.V., Tang, D.G., Gao, X., et al. 12-Lipoxygenases and 12(S)-HETE: Role in cancer metastasis. Cancer Metastasis Rev 13 365-396 (1994).

Billah, M.M., and Anthes, J.C. The regulation and cellular functions of phosphatidylcholine hydrolysis. Biochem J 269 281-291 (1990).

Mitropoulos, K.A. Lipid-thrombosis interface. Br Med Bull 50 813-832 (1994).

Münzel, T., Giad, A., Kurz, S., et al. Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance. Proc Natl Acad Sci USA 92 5244-5248 (1995).

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GW 7647 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $28.00 $0.00
5 mg $112.00 $0.00
10 mg $168.00 $0.00
25 mg $315.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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