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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Arachidonic Acid Leelamide

Cayman Chemical Item Number 10008617

Arachidonic Acid Leelamide

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Description

Arachidonic acid leelamide is the arachidonic amide analog of leelamine. Leelamine has weak affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, exhibiting 20% displacement of [3H]-CP55940 at a concentration of 10 µM.1 Leelamine inhibits pyruvate dehydrogenase kinase (PDK) with an IC50 value of 9.5 µM.2 Derivatives of leelamine exhibit anti-inflammatory activity and show moderate inhibition of phospholipase A2 activity from a variety of sources.3 There are no published studies of the pharmacological properties of arachidonic acid leelamide.

1 Martin, B.R. Leelamine. (2006 Apr 27).

2 Aicher, T.D., Damon, R.E., Koletar, J., et al. Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK). Bioorg Med Chem Lett 9 2223-2228 (1999).

3 Wilkerson, W., DeLucca, I., Galbraith, W., et al. Antiinflammatory phospholipase-A2 inhibitors. I. Eur J Med Chem 26 667-676 (1991).

Formal Name 1R,​2,​3,​4,​4aS,​9,​10,​10aR-​octahydro-​1,​4a-​dimethyl-​7-​(1-​methylethyl)-​1-​phenanthrene-​5Z,​8Z,​11Z,​14Z-​eicosatetraenamide
Molecular Formula C40H61NO
Formula Weight 571.9
Formulation A solution in ethanol
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)​NC[C@]​1(C)​CCC[C@]​2(C)​c3ccc(cc3CC[C@@H]​12)​C(C)​C

Background Reading

Martin, B.R. Leelamine. (2006 Apr 27).

Aicher, T.D., Damon, R.E., Koletar, J., et al. Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK). Bioorg Med Chem Lett 9 2223-2228 (1999).

Wilkerson, W., DeLucca, I., Galbraith, W., et al. Antiinflammatory phospholipase-A2 inhibitors. I. Eur J Med Chem 26 667-676 (1991).

Arachidonic Acid Leelamide is available in the following screening libraries:

Size Price Quantity Subtotal
5 mg $37.00 $0.00
10 mg $70.00 $0.00
50 mg $296.00 $0.00
100 mg $518.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-10. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Arachidonic Acid
Lauric Acid Leelamide
Leelamine
Leelamine (hydrochloride)
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