Cayman Chemical | Lauric Acid Leelamide

10008618 Lauric Acid Leelamide

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Lauric acid leelamide is the lauric (C-12) amide analog of leelamine. Leelamine has weak affinity for the human central cannabinoid (CB₁) and peripheral cannabinoid (CB₂) receptors, exhibiting 20% displacement of [³H]-CP55940 at a concentration of 10 µM.¹ Leelamine inhibits pyruvate dehydrogenase kinase (PDK) with an IC₅₀ value of 9.5 µM.² Derivatives of leelamine exhibit anti-inflammatory activity and show moderate inhibition of phospholipase A₂ activity from a variety of sources.³ There are no published studies of the pharmacological properties of lauric acid leelamide.

1 Martin, B.R. Leelamine. (2006 Apr 27).

2 Aicher, T.D., Damon, R.E., Koletar, J., et al. Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK). Biooganic & Medicinal Chemistry Letters 9 2223-2228 (1999).

3 Wilkerson, W., DeLucca, I., Galbraith, W., et al. Antiinflammatory phospholipase-A₂ inhibitors. I. Eur J Med Chem 26 667-676 (1991).

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Purchase 10008618 Lauric Acid Leelamide

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

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Warning This product is not for human or veterinary use.

Pricing updated 2010-03-18.
Prices are subject to change without notice.

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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.