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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Lauric Acid Leelamide

Cayman Chemical Item Number 10008618

Lauric Acid Leelamide

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Description

Lauric acid leelamide is the lauric (C-12) amide analog of leelamine. Leelamine has weak affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, exhibiting 20% displacement of [3H]-CP55940 at a concentration of 10 µM.1 Leelamine inhibits pyruvate dehydrogenase kinase (PDK) with an IC50 value of 9.5 µM.2 Derivatives of leelamine exhibit anti-inflammatory activity and show moderate inhibition of phospholipase A2 activity from a variety of sources.3 There are no published studies of the pharmacological properties of lauric acid leelamide.

1 Martin, B.R. Leelamine. (2006 Apr 27).

2 Aicher, T.D., Damon, R.E., Koletar, J., et al. Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK). Bioorg Med Chem Lett 9 2223-2228 (1999).

3 Wilkerson, W., DeLucca, I., Galbraith, W., et al. Antiinflammatory phospholipase-A2 inhibitors. I. Eur J Med Chem 26 667-676 (1991).

Formal Name 1R,​2,​3,​4,​4aS,​9,​10,​10aR-​octahydro-​1,​4a-​dimethyl-​7-​(1-​methylethyl)-​1-​phenanthrene-​dodecanamide
Molecular Formula C32H53NO
Formula Weight 467.8
Formulation A solution in ethanol
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CC(C)​C(C=C1)​=CC2=C1[C@]​3(C)​[C@]​(CC2)​([H]​)​[C@]​(C)​(CNC(CCCCCCCCCCC)​=O)​CCC3

Background Reading

Martin, B.R. Leelamine. (2006 Apr 27).

Aicher, T.D., Damon, R.E., Koletar, J., et al. Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK). Bioorg Med Chem Lett 9 2223-2228 (1999).

Wilkerson, W., DeLucca, I., Galbraith, W., et al. Antiinflammatory phospholipase-A2 inhibitors. I. Eur J Med Chem 26 667-676 (1991).

Lauric Acid Leelamide is available in the following screening libraries:

Size Price Quantity Subtotal
5 mg $46.00 $0.00
10 mg $87.00 $0.00
50 mg $368.00 $0.00
100 mg $644.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Arachidonic Acid Leelamide
Lauric Acid
Lauric Acid ethyl ester
Leelamine
Leelamine (hydrochloride)
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