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FTY720 Phosphate

Cayman Chemical Item Number 10008639

FTY720P (CAS 402615-91-2)

FTY720 Phosphate (CAS 402615-91-2)

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Description

FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.1 In vivo, FTY720 is phosphorylated by sphingosine kinase to the physiologically active phosphoric acid ester.2,3 FTY720 phosphate acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5), with IC50 values of 0.2-6 nM.2,3,4

1 Brinkmann, V., Pinschewer, D.D., Feng, L., et al. FTY720: Altered lymphocyte traffic results in allograft protection. Transplantation 72 764-769 (2001).

2 Brinkmann, V., Davis, M.D., Heise, C.E., et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 277(24) 21453-21457 (2002).

3 Mandala, S., Hajdu, R., Bergstrom, J., et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296 346-349 (2002).

4 Forrest, M., Sun, S., Hajdu, R., et al. Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. J Pharmacol Exp Ther 309(2) 758-768 (2004).

Synonyms
  • FTY720P
Formal Name 2-​amino-​2[2-​(4-​octylphenyl)ethyl]-​1,​3-​propanediol,​ mono dihydrogen phosphate ester
CAS Number 402615-91-2
Molecular Formula C19H34NO5P
Formula Weight 387.5
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCCCCCC1=CC=C(CCC([NH3+]​)​C(COP([O-]​)​(O)​=O)​O)​C=C1

Background Reading

Brinkmann, V., Pinschewer, D.D., Feng, L., et al. FTY720: Altered lymphocyte traffic results in allograft protection. Transplantation 72 764-769 (2001).

Mandala, S., Hajdu, R., Bergstrom, J., et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296 346-349 (2002).

Forrest, M., Sun, S., Hajdu, R., et al. Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. J Pharmacol Exp Ther 309(2) 758-768 (2004).

Brinkmann, V., Davis, M.D., Heise, C.E., et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 277(24) 21453-21457 (2002).

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Size Price Quantity Subtotal
1 mg $87.00 $0.00
5 mg $392.00 $0.00
10 mg $696.00 $0.00
25 mg $1,523.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

FTY720
Myriocin

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