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FTY720 Phosphate

Cayman Chemical Item Number 10008639

FTY720P (CAS 402615-91-2)

FTY720 Phosphate (CAS 402615-91-2)

See more	Ceramides/Sphingolipids (55) Immunology (181)

Description

FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.¹ In vivo, FTY720 is phosphorylated by sphingosine kinase to the physiologically active phosphoric acid ester.^2,3 FTY720 phosphate acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P₁, S1P₃, S1P₄, and S1P₅), with IC₅₀ values of 0.2-6 nM.^2,3,4

1 Brinkmann, V., Pinschewer, D.D., Feng, L., et al. FTY720: Altered lymphocyte traffic results in allograft protection. Transplantation 72 764-769 (2001).

2 Brinkmann, V., Davis, M.D., Heise, C.E., et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 277(24) 21453-21457 (2002).

3 Mandala, S., Hajdu, R., Bergstrom, J., et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296 346-349 (2002).

4 Forrest, M., Sun, S., Hajdu, R., et al. Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. J Pharmacol Exp Ther 309(2) 758-768 (2004).

Synonyms	FTY720P
Formal Name	2-amino-2[2-(4-octylphenyl)ethyl]-1,3-propanediol, mono dihydrogen phosphate ester
CAS Number	402615-91-2
Molecular Formula	C₁₉H₃₄NO₅P
Formula Weight	387.5
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCCCCC1=CC=C(CCC([NH3+])C(COP([O-])(O)=O)O)C=C1

Background Reading

Brinkmann, V., Pinschewer, D.D., Feng, L., et al. FTY720: Altered lymphocyte traffic results in allograft protection. Transplantation 72 764-769 (2001).

Mandala, S., Hajdu, R., Bergstrom, J., et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296 346-349 (2002).

Forrest, M., Sun, S., Hajdu, R., et al. Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. J Pharmacol Exp Ther 309(2) 758-768 (2004).

Brinkmann, V., Davis, M.D., Heise, C.E., et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 277(24) 21453-21457 (2002).

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Size	Price	Quantity	Subtotal
1 mg	$87.00		$0.00
5 mg	$392.00		$0.00
10 mg	$696.00		$0.00
25 mg	$1,523.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Related Products

FTY720

Myriocin

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