Prostaglandin F2α-d9

Prostaglandin F_2α-d₉

Cayman Chemical Item Number 10008643

Dinoprost-d₉

Description

Prostaglandin F_2α-d₉ (PGF_2α-d₉) contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of PGF_2α by GC- or LC-mass spectrometry. PGF_2α is a widely distributed PG occurring in many species.^1,2,3 It causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exhibits potent luteolytic activity.¹ PGF_2α exerts its receptor mediated physiological activity at 50-100 nM.¹ Maximal ovine myometrial contraction can be achieved at 125 nM PGF_2α in vitro.⁴

1 Samuelsson, B., Goldyne, M., Granström, E., et al. Prostaglandins and thromboxanes. Annu Rev Biochem 47 997-1029 (1978).

2 Speroff, L., and Ramwell, P.W. Prostaglandins in reproductive physiology. Am J Obstet Gynecol 107 1111-1130 (1970).

3 Watanabe, K., Iguchi, Y., Iguchi, S., et al. Stereospecific conversion of prostaglandin D₂ to (5Z,13E)-(15S)-9α,-11β,15-trihydroxyprosta-5,13-dien-1-oic acid (9α,11β-prostaglandin F2) and of prostaglandin H₂ to prostaglandin F_2α by bovine lung prostaglandin F synthase. Proc Natl Acad Sci USA 83 1583-1587 (1986).

4 Crankshaw, D.J., and Gaspar, V. Pharmacological characterization in vitro of prostanoid receptors in the myometrium of nonpregnant ewes. J Reprod Fertil 103 55-61 (1995).

Synonyms

Dinoprost-d9

Formal Name

9α,11α,15S-trihydroxy-prosta-5Z,13E-dien-1-oic-17,17,18,18,19,19,20,20,20-d9 acid

Molecular Formula

C₂₀H₂₅D₉O₅

Formula Weight

363.5

Formulation

A solution in methyl acetate

Purity

≥99% deuterated forms (d1-d9)

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

SMILES

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CCCCCC(O)/C=C/[C@H]1C(O)CC(O)C1C/C=C\CCCC(=O)O

Size

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Subtotal

25 µg 
$33.00

$0.00

50 µg 
$63.00

$0.00

100 µg 
$119.00

$0.00

500 µg 
$528.00

$0.00

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Prostaglandin F_2α-d₉