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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Prostaglandin F2α-d9

Cayman Chemical Item Number 10008643

Dinoprost-d9

Prostaglandin F2α-d9

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Description

Prostaglandin F2α-d9 (PGF2α-d9) contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of PGF2α by GC- or LC-mass spectrometry. PGF2α is a widely distributed PG occurring in many species.1,2,3 It causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exhibits potent luteolytic activity.1 PGF2α exerts its receptor mediated physiological activity at 50-100 nM.1 Maximal ovine myometrial contraction can be achieved at 125 nM PGF2α in vitro.4

1 Samuelsson, B., Goldyne, M., Granström, E., et al. Prostaglandins and thromboxanes. Annu Rev Biochem 47 997-1029 (1978).

2 Speroff, L., and Ramwell, P.W. Prostaglandins in reproductive physiology. Am J Obstet Gynecol 107 1111-1130 (1970).

3 Watanabe, K., Iguchi, Y., Iguchi, S., et al. Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9α,-11β,15-trihydroxyprosta-5,13-dien-1-oic acid (9α,11β-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2α by bovine lung prostaglandin F synthase. Proc Natl Acad Sci USA 83 1583-1587 (1986).

4 Crankshaw, D.J., and Gaspar, V. Pharmacological characterization in vitro of prostanoid receptors in the myometrium of nonpregnant ewes. J Reprod Fertil 103 55-61 (1995).

Synonyms
  • Dinoprost-d9
Formal Name 9α,​11α,​15S-​trihydroxy-​prosta-​5Z,​13E-​dien-​1-​oic-​17,​17,​18,​18,​19,​19,​20,​20,​20-​d9 acid
Molecular Formula C20H25D9O5
Formula Weight 363.5
Formulation A solution in methyl acetate
Purity ≥99% deuterated product
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCCC(O)​/C=C/[C@H]​1C(O)​CC(O)​C1C/C=C\CCCC(=O)​O
Size Price Quantity Subtotal
25 µg $33.00 $0.00
50 µg $63.00 $0.00
100 µg $119.00 $0.00
500 µg $528.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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